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<p>Nanobiotechnology seems to offer practical approaches for tackling antimicrobial resistant pathogens. This particular study looks at the biosynthesis of selenium nanoparticles (SeNPs) using red dragon fruit (<i>Hylocereus polyrhizus</i>) <i>mucilage</i> and its integration into chitosan (Cts) nanoparticles to form effective antimicrobial nanocomposites (Cts/DrF/SeNPs). Characterization of the materials was conducted using spectroscopy, electron microscopy, and some physicochemical analysis (e.g. FTIR and DLS). The infrared analyses revealed the involvement of biochemical groups in nanomaterial biosynthesis and interactions. The DrF/SeNPs exhibit semi-spherical morphology, a smooth surface, a narrow size distribution, and their poly-dispersion index was low. The measured particle sizes mean (Ps) of CtsNPs, DrF/SeNPs, and Cts/DrF/SeNPs were 128.22&#xa0;nm, 12.36&#xa0;nm, and 159.73&#xa0;nm, respectively. The recorded zeta potential was + 36.68 mV for CtsNPs, -26.77 mV for DrF/SeNPs, and + 30.89 mV for the Cts/DrF/SeNPs, respectively. Cts, DrF/SeNPs, and Cts/DrF/SeNPs, were tested for antibacterial and antifungal activities against <i>S. aureus</i> and <i>C. albicans</i> using qualitative, quantitative, and ultrastructural imaging techniques. MIC were (50.0, 47.5, and 27.5&#xa0;µg/mL) against <i>S. aureus</i> for Cts, DrF/SeNPs, and Cts/DrF/SeNPs, respectively. MIC were (47.5, 55.0 and 32.5&#xa0;µg/mL) against <i>C. albicans</i> for Cts, DrF/SeNPs, and Cts/DrF/SeNPs, respectively. The Cts/DrF/SeNPs-treated fabrics showed the maximum antimicrobial effects compared to those treated with DrF or DrF/SeNPs alone against both <i>S. aureus</i> and <i>C. albicans</i>. This provides new insight into the use of Cts/DrF/SeNPs as green antimicrobial agents in resistant skin infections treatment, thus helping develop new approaches to tackle resistant infections.</p>

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Antimicrobial Fabrics Loaded with Chitosan/Selenium Nanocomposite Biosynthesized with Red Dragon Fruit Mucilage to Suppress Resistant Skin Pathogens

  • 期刊论文

  • 发表日期：

    2026年3月19日

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  • Asmaa Abdella,
  • Mohamed E. El-Hefnawy,
  • Mohammed I. Orif,
  • Mohamed A. Ghandourah,
  • Mohsen M. El-Sherbiny,
  • Haddad A. El Rabey,
  • Ahmed A. Tayel

摘要

Nanobiotechnology seems to offer practical approaches for tackling antimicrobial resistant pathogens. This particular study looks at the biosynthesis of selenium nanoparticles (SeNPs) using red dragon fruit (Hylocereus polyrhizus) mucilage and its integration into chitosan (Cts) nanoparticles to form effective antimicrobial nanocomposites (Cts/DrF/SeNPs). Characterization of the materials was conducted using spectroscopy, electron microscopy, and some physicochemical analysis (e.g. FTIR and DLS). The infrared analyses revealed the involvement of biochemical groups in nanomaterial biosynthesis and interactions. The DrF/SeNPs exhibit semi-spherical morphology, a smooth surface, a narrow size distribution, and their poly-dispersion index was low. The measured particle sizes mean (Ps) of CtsNPs, DrF/SeNPs, and Cts/DrF/SeNPs were 128.22 nm, 12.36 nm, and 159.73 nm, respectively. The recorded zeta potential was + 36.68 mV for CtsNPs, -26.77 mV for DrF/SeNPs, and + 30.89 mV for the Cts/DrF/SeNPs, respectively. Cts, DrF/SeNPs, and Cts/DrF/SeNPs, were tested for antibacterial and antifungal activities against S. aureus and C. albicans using qualitative, quantitative, and ultrastructural imaging techniques. MIC were (50.0, 47.5, and 27.5 µg/mL) against S. aureus for Cts, DrF/SeNPs, and Cts/DrF/SeNPs, respectively. MIC were (47.5, 55.0 and 32.5 µg/mL) against C. albicans for Cts, DrF/SeNPs, and Cts/DrF/SeNPs, respectively. The Cts/DrF/SeNPs-treated fabrics showed the maximum antimicrobial effects compared to those treated with DrF or DrF/SeNPs alone against both S. aureus and C. albicans. This provides new insight into the use of Cts/DrF/SeNPs as green antimicrobial agents in resistant skin infections treatment, thus helping develop new approaches to tackle resistant infections.