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<p>Plant-derived polysaccharides have recently become a prominent material because of their promising biological activities. In this study, <i>Curcuma longa</i> debranched starch nanoparticles (STNPs) were synthesized using a nanoprecipitation method. The characterization of the synthesized STNPs was done by using various techniques. The SEM and TEM results demonstrated that the STNPs showed a spherical shape with a smooth surface with a range of 105–195&#xa0;nm in size, and showed a zeta potential of −20.7 ± 4.66 mV. The STNPs showed free radical scavenging activity with IC<sub>50</sub> value of 48 ± 5&#xa0;µg/mL, and 24.32 ± 2.14&#xa0;µg/mL for DPPH and ABTS free radical scavenging assays, respectively. The hemocompatibility of STNPs showed negligible toxicity. The STNPs exhibited anticancer activity against HepG2 cells (human hepatocellular carcinoma cells) (IC<sub>50</sub> of 304 ± 25&#xa0;µg/mL) in a dose-dependent manner. Moreover, STNPs exhibited antibacterial activity against <i>Corynebacterium diphtheriae</i> (6 ± 0.32&#xa0;mm), <i>Salmonella typhi</i> (2 ± 0.1&#xa0;mm), and <i>Escherichia coli</i> (4 ± 0.2&#xa0;mm) at a 200&#xa0;µg concentration, and the outcome was observed from the SEM study of bacterial membrane integrity. Moreover, STNPs at 400&#xa0;µg showed biofilm inhibition of 42% and 56% for <i>E.coli</i> and <i>C.diphtheriae</i>, respectively. In conclusion, STNPs exhibited substantial antioxidant, antibacterial, antibiofilm, and anticancer activities. Collectively, these results collectively suggest that STNPs have diverse functions of, showcasing their potential as antioxidants, anticancer agents, antibacterial agents and could be useful in biomedical applications.</p>

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An Engineered Curcuma longa Starch Nanoparticles: A multi-functional Biomaterial for anti-oxidant, anticancer, Antibacterial and anti-biofilm Agent

  • 期刊论文

  • 发表日期：

    2026年1月12日

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  • Siva Sankar Sana,
  • Ramakrishna Vadde,
  • Chaitany Jayprakash Raorane,
  • Pham Van Hung,
  • Tae Hwan Oh

摘要

Plant-derived polysaccharides have recently become a prominent material because of their promising biological activities. In this study, Curcuma longa debranched starch nanoparticles (STNPs) were synthesized using a nanoprecipitation method. The characterization of the synthesized STNPs was done by using various techniques. The SEM and TEM results demonstrated that the STNPs showed a spherical shape with a smooth surface with a range of 105–195 nm in size, and showed a zeta potential of −20.7 ± 4.66 mV. The STNPs showed free radical scavenging activity with IC50 value of 48 ± 5 µg/mL, and 24.32 ± 2.14 µg/mL for DPPH and ABTS free radical scavenging assays, respectively. The hemocompatibility of STNPs showed negligible toxicity. The STNPs exhibited anticancer activity against HepG2 cells (human hepatocellular carcinoma cells) (IC50 of 304 ± 25 µg/mL) in a dose-dependent manner. Moreover, STNPs exhibited antibacterial activity against Corynebacterium diphtheriae (6 ± 0.32 mm), Salmonella typhi (2 ± 0.1 mm), and Escherichia coli (4 ± 0.2 mm) at a 200 µg concentration, and the outcome was observed from the SEM study of bacterial membrane integrity. Moreover, STNPs at 400 µg showed biofilm inhibition of 42% and 56% for E.coli and C.diphtheriae, respectively. In conclusion, STNPs exhibited substantial antioxidant, antibacterial, antibiofilm, and anticancer activities. Collectively, these results collectively suggest that STNPs have diverse functions of, showcasing their potential as antioxidants, anticancer agents, antibacterial agents and could be useful in biomedical applications.