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<p>Molecularly imprinted polymers (MIPs) have gained significant popularity in various biomedical applications due to their efficiency and rapid growth as nano-platforms. In this investigation, nanoparticles of tramadol (Tr) imprinted magnetic polymer were designed based on chitosan through a precipitation polymerization of <i>N</i>,<i>N</i>-Methylenebisacrylamide ethylene, and methacrylic acid in an aqueous medium. The resulting magnetic chitosan MIPs (MCMIP) were utilized as nanocarriers to deliver Tr, exhibiting a high drug loading capacity and controlled release behavior. The prepared materials were thoroughly characterized using X-ray diffraction (XRD), Fourier Transform Infrared (FT-IR) spectroscopy, Dynamic Light Scattering (DLS), Thermal Gravimetric Analysis (TGA), Scanning Electron Microscopy (SEM), and zeta potential (ZP) measurements. In vitro studies on Tr loading (98% encapsulation efficiency) and release revealed that the maximum release of Tr (76.20%) occurred over 96&#xa0;h in the stimulated physiological environment (37&#xa0;°C, pH 7.4), exhibiting a sustained release profile. Notably, the cytotoxicity study demonstrated that the MCMIP exhibited good cytocompatibility (&gt; 70% cell viability at 100&#xa0;µg/mL for 48&#xa0;h) against Human umbilical vein endothelial cells (HUVEC). Based on the obtained results, the synthesized MCMIP shows excellent potential as a promising candidate for developing an efficient, safe, controlled-release nanocarrier.</p>

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Molecularly Imprinted Magnetic Chitosan/Polymethacrylic Acid as a Safe Nanocarrier for Highly Sustained Release of Tramadol

  • 期刊论文

  • 发表日期：

    2026年3月31日

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  • Ayda Saboury,
  • Siamak Javanbakht,
  • Reza Mohammadi,
  • Marjan Ghorbani

摘要

Molecularly imprinted polymers (MIPs) have gained significant popularity in various biomedical applications due to their efficiency and rapid growth as nano-platforms. In this investigation, nanoparticles of tramadol (Tr) imprinted magnetic polymer were designed based on chitosan through a precipitation polymerization of N,N-Methylenebisacrylamide ethylene, and methacrylic acid in an aqueous medium. The resulting magnetic chitosan MIPs (MCMIP) were utilized as nanocarriers to deliver Tr, exhibiting a high drug loading capacity and controlled release behavior. The prepared materials were thoroughly characterized using X-ray diffraction (XRD), Fourier Transform Infrared (FT-IR) spectroscopy, Dynamic Light Scattering (DLS), Thermal Gravimetric Analysis (TGA), Scanning Electron Microscopy (SEM), and zeta potential (ZP) measurements. In vitro studies on Tr loading (98% encapsulation efficiency) and release revealed that the maximum release of Tr (76.20%) occurred over 96 h in the stimulated physiological environment (37 °C, pH 7.4), exhibiting a sustained release profile. Notably, the cytotoxicity study demonstrated that the MCMIP exhibited good cytocompatibility (> 70% cell viability at 100 µg/mL for 48 h) against Human umbilical vein endothelial cells (HUVEC). Based on the obtained results, the synthesized MCMIP shows excellent potential as a promising candidate for developing an efficient, safe, controlled-release nanocarrier.