Scholarlink

<p>This work introduces a multifunctional wound dressing based on a polyhydroxyurethane (PHU) network primarily crosslinked with oxidized tannic acid (OTA). To tailor its properties, gelatin (GE) was added at different concentrations to improve biocompatibility and exudate management. A secondary crosslinking step, using either Fe(III) coordination or glutaraldehyde vapor, was then applied to enhance the mechanical strength in wet conditions while keeping flexibility. This approach produced two different dressing platforms: glutaraldehyde-crosslinked (GPHU/OTA/GE) and Fe(III)-crosslinked (FePHU/OTA/GE). The resulting materials combined features essential for advanced wound care. The dressings reached tensile strengths of up to ~ 4&#xa0;MPa and adhered strongly to skin, even on highly mobile joints. The very good adhesion strength of about 15&#xa0;kPa to tissue imitating substrate (gelatin sheet) was recorded for both categories of these dressings. They could handle fluids at capacities of 2.5–3.6&#xa0;g/10 cm<sup>2</sup>/day and had a water vapor transmission rate of 1881–3137&#xa0;g/m<sup>2</sup>/day, suitable for low-to-moderate exuding wounds. The OTA crosslinker provided a strong photothermal effect, reaching surface temperatures of &gt; 50&#xa0;°C under NIR irradiation to kill Gram-positive and Gram-negative bacteria, along with excellent natural antioxidant activity. Cytocompatibility tests confirmed safety, with fibroblast viability exceeding 100% in MTT assays and over 90% wound closure within 24&#xa0;h in scratch assays. Based on performance evaluations, FePHU/TA/GE series is advised for wounds with moderate exudate levels owing to its excellent mechanical strength and integrity, whereas GPHU/TA/GE series is the optimal choice for low-exudate infected wounds because of its outstanding antibacterial efficacy.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Self-Adhesive, Conformable Polyhydroxyurethane-Tannic Acid Wound Dressings with Antioxidant and Photothermally Induced Antibacterial Activities

  • 期刊论文

  • 发表日期：

    2026年3月11日

查看全文
  • Parsa Mousavi,
  • Hamid Yeganeh,
  • Masoud Babaahmadi

摘要

This work introduces a multifunctional wound dressing based on a polyhydroxyurethane (PHU) network primarily crosslinked with oxidized tannic acid (OTA). To tailor its properties, gelatin (GE) was added at different concentrations to improve biocompatibility and exudate management. A secondary crosslinking step, using either Fe(III) coordination or glutaraldehyde vapor, was then applied to enhance the mechanical strength in wet conditions while keeping flexibility. This approach produced two different dressing platforms: glutaraldehyde-crosslinked (GPHU/OTA/GE) and Fe(III)-crosslinked (FePHU/OTA/GE). The resulting materials combined features essential for advanced wound care. The dressings reached tensile strengths of up to ~ 4 MPa and adhered strongly to skin, even on highly mobile joints. The very good adhesion strength of about 15 kPa to tissue imitating substrate (gelatin sheet) was recorded for both categories of these dressings. They could handle fluids at capacities of 2.5–3.6 g/10 cm2/day and had a water vapor transmission rate of 1881–3137 g/m2/day, suitable for low-to-moderate exuding wounds. The OTA crosslinker provided a strong photothermal effect, reaching surface temperatures of > 50 °C under NIR irradiation to kill Gram-positive and Gram-negative bacteria, along with excellent natural antioxidant activity. Cytocompatibility tests confirmed safety, with fibroblast viability exceeding 100% in MTT assays and over 90% wound closure within 24 h in scratch assays. Based on performance evaluations, FePHU/TA/GE series is advised for wounds with moderate exudate levels owing to its excellent mechanical strength and integrity, whereas GPHU/TA/GE series is the optimal choice for low-exudate infected wounds because of its outstanding antibacterial efficacy.

Graphical abstract