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<p>Poly(ε-caprolactone) (PCL) scaffolds face dual challenges of insufficient mechanical strength and poor bioactivity. To address these limitations, multi-walled carbon nanotubes (MWCNTs) modified with sodium dodecylbenzene sulfonate (SDBS) were introduced into the PCL matrix as reinforcing phases. Triply periodic minimal surface (TPMS) structured PCL/SDBS-modified MWCNTs (S-MWCNTs) composite scaffolds were fabricated using selective laser sintering (SLS) technology. The experimental results show that SDBS can effectively improve the agglomeration of MWCNTs through electrostatic repulsion. The ultimate tensile strength of the composite scaffold containing 0.75 wt% S-modified MWCNTs reached 11.08&#xa0;MPa, representing a 269.33% increase compared to that of the PCL scaffold (3&#xa0;MPa), primarily due to the bridging and pull-out effects of MWCNTs. Additionally, compared to the unmodified 0.75 wt% MWCNTs composite scaffold, the tensile strength was further improved by 52.33%, which is attributed to the more uniform dispersion of MWCNTs after SDBS modification. In addition, the composite scaffold exhibited enhanced hydrophilicity and demonstrated favorable apatite-forming ability in simulated body fluid (SBF). Cytocompatibility experiments (live/dead staining) further confirmed their favorable bioactivity and cell compatibility. These results demonstrate that the S-MWCNTs reinforced PCL composite scaffold exhibits enhanced mechanical properties and bioactivity, indicating its potential as a candidate material for bone tissue engineering applications.</p>

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Modified MWCNTs Endowed PCL Scaffolds with Improved Mechanical and Bioactivity

  • 期刊论文

  • 发表日期：

    2025年9月29日

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  • Jianfei Zhang,
  • Dongying Li,
  • Meigui Chen,
  • Bin Wang,
  • Bo Xu,
  • Zixiong Zhou,
  • Zonghan Li,
  • Mengqi Li,
  • Yong Xu

摘要

Poly(ε-caprolactone) (PCL) scaffolds face dual challenges of insufficient mechanical strength and poor bioactivity. To address these limitations, multi-walled carbon nanotubes (MWCNTs) modified with sodium dodecylbenzene sulfonate (SDBS) were introduced into the PCL matrix as reinforcing phases. Triply periodic minimal surface (TPMS) structured PCL/SDBS-modified MWCNTs (S-MWCNTs) composite scaffolds were fabricated using selective laser sintering (SLS) technology. The experimental results show that SDBS can effectively improve the agglomeration of MWCNTs through electrostatic repulsion. The ultimate tensile strength of the composite scaffold containing 0.75 wt% S-modified MWCNTs reached 11.08 MPa, representing a 269.33% increase compared to that of the PCL scaffold (3 MPa), primarily due to the bridging and pull-out effects of MWCNTs. Additionally, compared to the unmodified 0.75 wt% MWCNTs composite scaffold, the tensile strength was further improved by 52.33%, which is attributed to the more uniform dispersion of MWCNTs after SDBS modification. In addition, the composite scaffold exhibited enhanced hydrophilicity and demonstrated favorable apatite-forming ability in simulated body fluid (SBF). Cytocompatibility experiments (live/dead staining) further confirmed their favorable bioactivity and cell compatibility. These results demonstrate that the S-MWCNTs reinforced PCL composite scaffold exhibits enhanced mechanical properties and bioactivity, indicating its potential as a candidate material for bone tissue engineering applications.