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<p>In this study, bio-based hydrogels were designed and synthesized using the HEMA-TA-PEG macromer. The chemical structure of the macromer was confirmed through FTIR and <sup>1</sup>H-NMR analyses. Hydrogels with varying crosslinker (GPTMS) content were fabricated to investigate the impact of GPTMS on swelling, gel content, and mechanical properties. As the GPTMS content increased, the swelling behavior of the hydrogels decreased, whereas the gel content increased. Mechanical testing revealed a significant increase in tensile strength, with stress rising from 517&#xa0;kPa to 786&#xa0;kPa and the tensile modulus reaching 1.03&#xa0;MPa as the GPTMS content increased from 0.25&#xa0;g to 1&#xa0;g. The prepared hydrogels exhibited excellent cytocompatibility, with significantly higher cell viability than the control over time (24, 48, and 72&#xa0;h). Furthermore, cell adhesion in the hydrogels reached 93% at 48&#xa0;h, a significant increase compared to the 85% observed in the control. These findings highlight the potential of bio-based hydrogels for applications in regenerative medicine.</p><p></p>

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Synthesis of New macromer Based on HEMA-TA-PEG for Preparation of Bio-Based Hydrogels for Regenerative Medicine Applications

  • 期刊论文

  • 发表日期：

    2025年5月17日

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  • Hossein Rayat Pisheh,
  • Alireza Sabzevari,
  • Mojtaba Ansari,
  • Kourosh Kabiri,
  • Hossein Eslami,
  • Mohammad Kohestanian

摘要

In this study, bio-based hydrogels were designed and synthesized using the HEMA-TA-PEG macromer. The chemical structure of the macromer was confirmed through FTIR and 1H-NMR analyses. Hydrogels with varying crosslinker (GPTMS) content were fabricated to investigate the impact of GPTMS on swelling, gel content, and mechanical properties. As the GPTMS content increased, the swelling behavior of the hydrogels decreased, whereas the gel content increased. Mechanical testing revealed a significant increase in tensile strength, with stress rising from 517 kPa to 786 kPa and the tensile modulus reaching 1.03 MPa as the GPTMS content increased from 0.25 g to 1 g. The prepared hydrogels exhibited excellent cytocompatibility, with significantly higher cell viability than the control over time (24, 48, and 72 h). Furthermore, cell adhesion in the hydrogels reached 93% at 48 h, a significant increase compared to the 85% observed in the control. These findings highlight the potential of bio-based hydrogels for applications in regenerative medicine.