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<p>Tetrahydropyrimidines (THPMs), which are made from the Biginelli reaction, have been studied a lot for their possible biological uses, but they have not been considered as low-molecular-weight organogelators (LMOGs). Organogels, formed by combining LMOGs with organic solvents to create self-assembled nanoscale fibers, represent a significant area of study. In this work, a series of symmetrical THPMs starting from vanillic aldehyde were synthesized. Five novel THPMs were isolated, characterized, and evaluated for their gelation properties. Also, the possibility of fine-tuning the rheological properties of the organogel with the addition of a small content (2 wt%) of SiO<sub>2</sub> nanoparticles (average size 7&#xa0;nm) was investigated, which was achieved. Scanning electron microscopy (SEM) confirmed that the organogels formed a self-assembling 3D network. This research shows a creative way to use vanillin as a bio-based building block to synthesis THPMs. These THPMs, when added to organogels, make a stable and effective way to deliver antioxidants. Organogels developed in this study present a promising strategy for protecting the skin and promoting wound healing by effectively combating oxidative stress.</p>

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Synthesis of Organogels Loaded with Biginelli Twins Derived from Vanillin: Antioxidative Potential for Wound and Skin Protection

  • 期刊论文

  • 发表日期：

    2025年4月10日

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  • Nenad Janković,
  • Emilija Milović,
  • Ana Rilak Simović,
  • Sebastian Baloš,
  • Nenad Ignjatović,
  • Miroslav Cvetinov,
  • Miroslav Hadnadjev,
  • Dušan Milivojević

摘要

Tetrahydropyrimidines (THPMs), which are made from the Biginelli reaction, have been studied a lot for their possible biological uses, but they have not been considered as low-molecular-weight organogelators (LMOGs). Organogels, formed by combining LMOGs with organic solvents to create self-assembled nanoscale fibers, represent a significant area of study. In this work, a series of symmetrical THPMs starting from vanillic aldehyde were synthesized. Five novel THPMs were isolated, characterized, and evaluated for their gelation properties. Also, the possibility of fine-tuning the rheological properties of the organogel with the addition of a small content (2 wt%) of SiO2 nanoparticles (average size 7 nm) was investigated, which was achieved. Scanning electron microscopy (SEM) confirmed that the organogels formed a self-assembling 3D network. This research shows a creative way to use vanillin as a bio-based building block to synthesis THPMs. These THPMs, when added to organogels, make a stable and effective way to deliver antioxidants. Organogels developed in this study present a promising strategy for protecting the skin and promoting wound healing by effectively combating oxidative stress.