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<p>Managing open wounds is difficult because of the risk of bacterial infections and moisture loss, which can delay healing. Advanced wound care solutions are essential for healing. Hydrogel bandages provide a promising option because of the unique features of hydrogel such as high porosity and absorbency from its hydrophilic polymer composition. In addition, advanced hydrogel dressings infused with nanotechnology, especially zinc oxide–copper oxide (ZnO–CuO) nanocomposites, remarkably improve the effectiveness of wound care strategies. In the current study, the mechanochemistry, antibacterial efficacy, cytocompatibility and wound healing potential of ZnO–CuO nanocomposite-embedded polyethylene glycol hydrogel (CPZCH) were investigated. Antibacterial profiles were examined by disc diffusion, time-kill tests, and bacterial cell adherence against&#xa0;<i>S. aureus</i>,&#xa0;<i>MRSA</i>,&#xa0;<i>P. aeruginosa</i> and&#xa0;<i>E. coli</i>. Cytocompatibility and wound healing profiles were studied using the fibroblast cells. CPZCH exhibited favourable swelling‐shrinkable behaviours with a swelling, porosity and degradation ratio of approximately 1920.45%, 142.86% and 60.27%, respectively. These characteristics are crucial for maintaining a moist wound environment, facilitating nutrient distribution and making eco-friendly dressings. CPZCH exhibited antibacterial potential within 24h, which is crucial for managing infection and protecting wounds from bacterial infections. CPZCH exhibited high cytocompatibility (~ 110.177%) and remarkable&#xa0;<i>in vitro</i>wound healing properties within 48h, which are crucial for maintaining cell integrity from toxicity and rapid wound closure. Therefore, CPZCH showed great application potential in wound dressing with favourable swelling‐shrinkable behaviours, antibacterial efficacy, cytocompatibility and wound healing properties. Further&#xa0;studies especially involving hemocompatibility and molecular interaction are necessary to reach comprehensive knowledge about the behaviour of the dressing in wound management.</p> Graphical abstract <p></p>

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Advanced Hydrogel Dressing with Zinc Oxide-Copper Oxide Nanocomposite for Effective Wound Management: Mechanochemistry, Antibacterial Efficacy, Cytocompatibility and Wound Healing Potentials

  • 期刊论文

  • 发表日期：

    2025年1月25日

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  • Nasrin K. Ramtan Gadaime,
  • Rabiatul Basria S. M. N. Mydin,
  • G. Ambarasan Govindasamy,
  • Yazmin Bustami,
  • Srimala Sreekantan

摘要

Managing open wounds is difficult because of the risk of bacterial infections and moisture loss, which can delay healing. Advanced wound care solutions are essential for healing. Hydrogel bandages provide a promising option because of the unique features of hydrogel such as high porosity and absorbency from its hydrophilic polymer composition. In addition, advanced hydrogel dressings infused with nanotechnology, especially zinc oxide–copper oxide (ZnO–CuO) nanocomposites, remarkably improve the effectiveness of wound care strategies. In the current study, the mechanochemistry, antibacterial efficacy, cytocompatibility and wound healing potential of ZnO–CuO nanocomposite-embedded polyethylene glycol hydrogel (CPZCH) were investigated. Antibacterial profiles were examined by disc diffusion, time-kill tests, and bacterial cell adherence against S. aureus, MRSA, P. aeruginosa and E. coli. Cytocompatibility and wound healing profiles were studied using the fibroblast cells. CPZCH exhibited favourable swelling‐shrinkable behaviours with a swelling, porosity and degradation ratio of approximately 1920.45%, 142.86% and 60.27%, respectively. These characteristics are crucial for maintaining a moist wound environment, facilitating nutrient distribution and making eco-friendly dressings. CPZCH exhibited antibacterial potential within 24h, which is crucial for managing infection and protecting wounds from bacterial infections. CPZCH exhibited high cytocompatibility (~ 110.177%) and remarkable in vitrowound healing properties within 48h, which are crucial for maintaining cell integrity from toxicity and rapid wound closure. Therefore, CPZCH showed great application potential in wound dressing with favourable swelling‐shrinkable behaviours, antibacterial efficacy, cytocompatibility and wound healing properties. Further studies especially involving hemocompatibility and molecular interaction are necessary to reach comprehensive knowledge about the behaviour of the dressing in wound management.

Graphical abstract