The topological semimetal YPtBi has attracted considerable attention, owing to its novel superconducting and normal state properties. A strong band inversion from spin-orbit coupling allows the existence of \(j=3/2\) quasi-particles near the Fermi level, which form Cooper pairs with angular momentum potentially higher than single or triplet states. In this report, we present high-pressure magnetotransport and Shubnikov-de Haas effect measurements on high-quality YPtBi up to \(P = 2.08\) GPa. As a function of pressure, we observe a trend toward more insulating resistivity at low temperatures concomitant with a suppression of quantum oscillation amplitude. Together with a decrease of the upper critical field and significant increase in the Dingle temperature, the pressure-induced changes point to a weakening of the band inversion and potential tuning of the topological nature of YPtBi, suggesting pressure as a useful tool for understanding the nature of topology in other related half-Heusler compounds.
