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<p>Metal-Organic Frameworks (MOFs) have garnered substantial attention for biomedical applications due to their unique properties, including high surface area, tunable porosity, and ease of functionalization. This review comprehensively examines recent advancements in MOFs for various biomedical applications, including drug delivery, cancer therapy, bioimaging, and wound healing. The synthesis methodologies, including solvothermal, microwave-assisted, sonochemical, and electrochemical techniques, are critically analyzed for their impact on MOF properties and biomedical efficacy. Additionally, the review addresses challenges such as MOF toxicity arising from reactive oxygen species generation and potential mitigation strategies through surface modifications and green chemistry approaches. Current limitations in the scalability and clinical translation of MOFs are highlighted, along with opportunities for optimizing their biomedical applications. Future directions emphasize the need for precise control over MOF synthesis and toxicity management to unlock their full potential for clinical use in drug delivery, imaging, and therapeutic interventions.</p>

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Biomedical Applications of Metal Organic Frameworks (MOFs): Insights Into Recent Developments, Current Challenges and Future Directions

  • 期刊论文

  • 发表日期：

    2026年6月22日

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  • S. Hemavathy,
  • Neha Sharma,
  • Deepak Sharma,
  • Lohith Dasarahally Kumar Huligowda,
  • Mridul Umesh,
  • Pritha Chakraborty,
  • Basheer Thazeem,
  • Vinay Kumar

摘要

Metal-Organic Frameworks (MOFs) have garnered substantial attention for biomedical applications due to their unique properties, including high surface area, tunable porosity, and ease of functionalization. This review comprehensively examines recent advancements in MOFs for various biomedical applications, including drug delivery, cancer therapy, bioimaging, and wound healing. The synthesis methodologies, including solvothermal, microwave-assisted, sonochemical, and electrochemical techniques, are critically analyzed for their impact on MOF properties and biomedical efficacy. Additionally, the review addresses challenges such as MOF toxicity arising from reactive oxygen species generation and potential mitigation strategies through surface modifications and green chemistry approaches. Current limitations in the scalability and clinical translation of MOFs are highlighted, along with opportunities for optimizing their biomedical applications. Future directions emphasize the need for precise control over MOF synthesis and toxicity management to unlock their full potential for clinical use in drug delivery, imaging, and therapeutic interventions.