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<p>Scientific studies confirm that trans-ferulic acid (TF), a phenolic acid, possesses various advantageous characteristics, such as antioxidant, anti-inflammatory, anticancer, and bacteria-combating effects. Its bioavailability is constrained by its limited solubility and absorption within biological systems, thus by formulating TF in nanoscale form this limitation can be overcome and its capacity for therapeutic applications can be increased. This research aimed to elucidate the capacity of TF to synthesize and stabilize selenium nanoparticles (TF-SeNPs), determine its physico-chemical properties, and evaluate its bioactivity and biocompatibility in different models. Spectroscopy analyses confirmed the successful synthesis of TF-SeNPs. Electron microscopy study (FE-SEM) revealed the presence of spherical particles with an average diameter of 48.8 ± 13.2&#xa0;nm and a zeta potential of -24.37 mV. Compared to the Gram-negative bacteria, TF-SeNPs indicated higher antibacterial activity against Gram-positive <i>Staphylococcus aureus</i> with an MIC of 15. 62&#xa0;µg/mL. These SeNPs suppressed the proliferation of breast MCF-7 tumor cells by 44.14 ± 1.3%, but showed cytocompatibility against normal fibroblast cells and human red blood cells (RBCs). In addition, TF-SeNPs had significantly higher DPPH radicals scavenging ability (65.8% at 600&#xa0;µg/mL), RBCs membrane integrity (93.1% at 800&#xa0;µg/mL), and protein structure protection activity (90.86% at 100&#xa0;µg/mL), indicating their strong anti-inflammatory potential. Based on the promising properties of TF-SeNPs, they may be used in pharmaceutical and biomedical applications.</p>

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Selenium Nanoparticles Stabilized by Trans-Ferulic Acid: Multitarget In Vitro Biogenesis, Biosafety, and Bioactivity in Different Systems and Models

  • 期刊论文

  • 发表日期：

    2026年6月19日

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  • Azam Chahardoli,
  • Ali Mostafaei

摘要

Scientific studies confirm that trans-ferulic acid (TF), a phenolic acid, possesses various advantageous characteristics, such as antioxidant, anti-inflammatory, anticancer, and bacteria-combating effects. Its bioavailability is constrained by its limited solubility and absorption within biological systems, thus by formulating TF in nanoscale form this limitation can be overcome and its capacity for therapeutic applications can be increased. This research aimed to elucidate the capacity of TF to synthesize and stabilize selenium nanoparticles (TF-SeNPs), determine its physico-chemical properties, and evaluate its bioactivity and biocompatibility in different models. Spectroscopy analyses confirmed the successful synthesis of TF-SeNPs. Electron microscopy study (FE-SEM) revealed the presence of spherical particles with an average diameter of 48.8 ± 13.2 nm and a zeta potential of -24.37 mV. Compared to the Gram-negative bacteria, TF-SeNPs indicated higher antibacterial activity against Gram-positive Staphylococcus aureus with an MIC of 15. 62 µg/mL. These SeNPs suppressed the proliferation of breast MCF-7 tumor cells by 44.14 ± 1.3%, but showed cytocompatibility against normal fibroblast cells and human red blood cells (RBCs). In addition, TF-SeNPs had significantly higher DPPH radicals scavenging ability (65.8% at 600 µg/mL), RBCs membrane integrity (93.1% at 800 µg/mL), and protein structure protection activity (90.86% at 100 µg/mL), indicating their strong anti-inflammatory potential. Based on the promising properties of TF-SeNPs, they may be used in pharmaceutical and biomedical applications.