<p>Curcumin-modified silver nanoparticles (Cur-AgNPs) were synthesized through a green approach and incorporated into a polysulfone (PSF) matrix to fabricate Cur-AgNPs/PSF mixed matrix membranes (MMMs<b>)</b>. Subsequently, their separation, antibacterial, antibiofouling, and antioxidant characteristics were examined. The research findings demonstrated that during the nonsolvent-induced phase separation (NIPS), the hydrophilic ligand (AgNPs) of the Cur-AgNPs amphiphilic additives segregated towards the polymer/water interface, while the hydrophobic portion (Cur) was firmly anchored within the polymer matrix, leading to partial surface enrichment. The obtained Cur-AgNPs/PSF MMMs displayed uniform dispersion along with surface enrichment. Compared with the pristine PSF membrane, the Cur-AgNPs/PSF MMMs demonstrated superior performance, with the pure water flux attaining 328.92&#xa0;L·m^− 2·h^− 1·bar ^− 1 and the BSA rejection rate rising to 91.23%. The membranes also manifested favorable antibacterial activity against <i>Staphylococcus aureus</i> (<i>S. aureus</i>) and <i>Escherichia coli</i> (<i>E. coli</i>). After fouling by <i>S. aureus</i> and <i>E. coli</i>, the flux recovery ratio reached 70–80%, which was notably higher than that of the PSF membrane. Additionally, the Cur-AgNPs/PSF MMMs displayed excellent free radical scavenging capacity. The incorporation of the amphiphilic Cur-AgNPs effectively enhanced the separation performance and antibiofouling property of PSF membranes.</p>