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<p>A newly constructed ternary hybrid system emphasizes the improved multifunctional performance COF<sub>3</sub>/CMC/CuFe<sub>2</sub>O<sub>4</sub> ternary hybrid nanocomposite was formed by means of a stepwise strategy for a multifunctional bioactive material. COF<sub>3</sub> provides the structural integrity of the polymeric framework; CMC is hydrophilic and biocompatible, while CuFe<sub>2</sub>O<sub>4</sub> has active inorganic properties. Successful composite formation and interfacial compatibility, as well as incorporation of the metal oxide phase into the organic/polymeric matrix, were established through FT-IR, SEM, and XRD analyses. The biological performance of COF<sub>3</sub>, COF<sub>3</sub>/CMC, and COF<sub>3</sub>/CMC/CuFe<sub>2</sub>O<sub>4</sub> composites was compared in terms of antioxidant, antimicrobial, and antibiofilm properties. The COF<sub>3</sub>/CMC/CuFe<sub>2</sub>O<sub>4</sub> hybrid exhibited the greatest degree of activity, with a DPPH radical scavenging value of 75.07 ± 1.83% and an ABTS value of 73.84 ± 0.66%, as well as superior antibacterial and antibiofilm properties compared to both COF<sub>3</sub> and COF<sub>3</sub>/CMC composites. Molecular docking studies showed that COF<sub>3</sub>/CMC/CuFe<sub>2</sub>O<sub>4</sub> exhibited more favorable binding interactions with antioxidant, antimicrobial, and antibiofilm targets than the other tested materials. Therefore, the results demonstrate that progressive hybridization of COF<sub>3</sub> with CMC and CuFe<sub>2</sub>O<sub>4</sub> enhances structure-dependent bioactivity and identifies COF<sub>3</sub>/CMC/CuFe<sub>2</sub>O<sub>4</sub> as a promising multifunctional hybrid nanocomposite for biomedical and antimicrobial applications.</p>

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Design and Bio Evaluation of a COF3/CMC/CuFe2O4 Hybrid Material: Experimental Characterization and Computational Validation

  • 期刊论文

  • 发表日期：

    2026年6月19日

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  • Asmaa M. Fahim,
  • Gharieb S. El-Sayyad,
  • Ahmed A. Hamed,
  • Mohamed E. El Awady

摘要

A newly constructed ternary hybrid system emphasizes the improved multifunctional performance COF3/CMC/CuFe2O4 ternary hybrid nanocomposite was formed by means of a stepwise strategy for a multifunctional bioactive material. COF3 provides the structural integrity of the polymeric framework; CMC is hydrophilic and biocompatible, while CuFe2O4 has active inorganic properties. Successful composite formation and interfacial compatibility, as well as incorporation of the metal oxide phase into the organic/polymeric matrix, were established through FT-IR, SEM, and XRD analyses. The biological performance of COF3, COF3/CMC, and COF3/CMC/CuFe2O4 composites was compared in terms of antioxidant, antimicrobial, and antibiofilm properties. The COF3/CMC/CuFe2O4 hybrid exhibited the greatest degree of activity, with a DPPH radical scavenging value of 75.07 ± 1.83% and an ABTS value of 73.84 ± 0.66%, as well as superior antibacterial and antibiofilm properties compared to both COF3 and COF3/CMC composites. Molecular docking studies showed that COF3/CMC/CuFe2O4 exhibited more favorable binding interactions with antioxidant, antimicrobial, and antibiofilm targets than the other tested materials. Therefore, the results demonstrate that progressive hybridization of COF3 with CMC and CuFe2O4 enhances structure-dependent bioactivity and identifies COF3/CMC/CuFe2O4 as a promising multifunctional hybrid nanocomposite for biomedical and antimicrobial applications.