Scholarlink

<p>Janus nano/micromotors (JNMMs) can move in a controllable manner and deliver drugs to the target tissue with high precision due to their anisotropic structures. In particular, platinum-based JNMMs (Pt-JNMMs) have demonstrated superior performance over other hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-driven micromotors, positioning them as promising candidates for targeted drug delivery in cancer treatment. In this study, we synthesized a platinum-based Janus micromotor (Pt-JMM) by conjugating alumina nanotubes with mesoporous silica nanoparticles (MSNPs) coated with polydopamine (PD) and platinum nanoparticles (Pt NPs). This micromotor is engineered to facilitate the loading and multi-responsive release of lomustine, an anticancer drug, triggered by pH, near infrared (NIR) light, and hydrogen peroxide. The maximum drug release amount was achieved in the presence of hydrogen peroxide (0.1% w/v), paired with NIR light irradiation in phosphate buffer solution with a pH of 5.8. In addition, the motion dynamics of the micromotors were assessed across varying concentrations of H<sub>2</sub>O<sub>2</sub> fuel (0.1 to 5% w/v). At the optimal concentration of 3% w/v, the diffusion coefficient of the synthesized micromotor was calculated to be about 273 µm<sup>2</sup>/s. The synthesized micromotors inhibit bacterial biofilm formation at a minimum inhibitory concentration (MIC) of approximately 10&#xa0;mg/ml and have potential for use in combination therapy with targeted chemotherapy and photothermal therapy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Nanoarchitectonics of Janus Nanotubes-Spheres Micromotors Based on Nanoporous Anodic Aluminum Oxide and Mesoporous Silica Nanoparticles Decorated with Polydopamine for On–Off Release of Lomustine

  • 期刊论文

  • 发表日期：

    2026年4月4日

查看全文
  • Samaneh Moayeri,
  • Sepideh Khoee

摘要

Janus nano/micromotors (JNMMs) can move in a controllable manner and deliver drugs to the target tissue with high precision due to their anisotropic structures. In particular, platinum-based JNMMs (Pt-JNMMs) have demonstrated superior performance over other hydrogen peroxide (H2O2)-driven micromotors, positioning them as promising candidates for targeted drug delivery in cancer treatment. In this study, we synthesized a platinum-based Janus micromotor (Pt-JMM) by conjugating alumina nanotubes with mesoporous silica nanoparticles (MSNPs) coated with polydopamine (PD) and platinum nanoparticles (Pt NPs). This micromotor is engineered to facilitate the loading and multi-responsive release of lomustine, an anticancer drug, triggered by pH, near infrared (NIR) light, and hydrogen peroxide. The maximum drug release amount was achieved in the presence of hydrogen peroxide (0.1% w/v), paired with NIR light irradiation in phosphate buffer solution with a pH of 5.8. In addition, the motion dynamics of the micromotors were assessed across varying concentrations of H2O2 fuel (0.1 to 5% w/v). At the optimal concentration of 3% w/v, the diffusion coefficient of the synthesized micromotor was calculated to be about 273 µm2/s. The synthesized micromotors inhibit bacterial biofilm formation at a minimum inhibitory concentration (MIC) of approximately 10 mg/ml and have potential for use in combination therapy with targeted chemotherapy and photothermal therapy.