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<p>Nasopharyngeal carcinoma (NPC) remains a malignant tumor with high invasiveness and poor prognosis, highlighting the urgent need for more effective therapeutic strategies. In this study, a zinc-based coordination polymer (Zn-CP1) was constructed and further engineered into a chitosan-coated, shikonin-loaded nanocomposite (CS@Zn-CP1@SK) with dual catalytic and therapeutic functionality. The nanoplatform exhibited high drug-loading capacity, pH/GSH-responsive release behavior, and notable peroxidase (POD)-like catalytic activity under tumor-mimicking conditions. The catalytic mechanism involves Zn–O coordination-assisted H<sub>2</sub>O<sub>2</sub> conversion to •OH radicals, which was further enhanced by GSH-induced redox activation and chitosan-mediated electron transfer. In vitro experiments revealed that CS@Zn-CP1@SK effectively inhibited proliferation of C666-1 nasopharyngeal carcinoma cells and significantly downregulated the anti-apoptotic gene Bcl-2, outperforming free shikonin. These results suggest that CS@Zn-CP1@SK functions as a multifunctional nanoenzyme system that integrates catalytic therapy and targeted drug delivery, providing a promising strategy for precise and efficient treatment of nasopharyngeal carcinoma.</p>

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Development of a Chitosan-Coated Zinc Coordination Polymer Hybrid Enabling Catalysis-Assisted Shikonin Delivery for Nasopharyngeal Carcinoma Therapy

  • 期刊论文

  • 发表日期：

    2026年4月4日

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  • Huanlai Huang,
  • Meiqing Lu,
  • Yanxian Liang,
  • Kaiyuan Huang,
  • Xiaoyan Wang,
  • Zhengquan Luo,
  • Jiahui Wu,
  • Xiaopeng Luo,
  • Jinhua Wang,
  • Jin Liu

摘要

Nasopharyngeal carcinoma (NPC) remains a malignant tumor with high invasiveness and poor prognosis, highlighting the urgent need for more effective therapeutic strategies. In this study, a zinc-based coordination polymer (Zn-CP1) was constructed and further engineered into a chitosan-coated, shikonin-loaded nanocomposite (CS@Zn-CP1@SK) with dual catalytic and therapeutic functionality. The nanoplatform exhibited high drug-loading capacity, pH/GSH-responsive release behavior, and notable peroxidase (POD)-like catalytic activity under tumor-mimicking conditions. The catalytic mechanism involves Zn–O coordination-assisted H2O2 conversion to •OH radicals, which was further enhanced by GSH-induced redox activation and chitosan-mediated electron transfer. In vitro experiments revealed that CS@Zn-CP1@SK effectively inhibited proliferation of C666-1 nasopharyngeal carcinoma cells and significantly downregulated the anti-apoptotic gene Bcl-2, outperforming free shikonin. These results suggest that CS@Zn-CP1@SK functions as a multifunctional nanoenzyme system that integrates catalytic therapy and targeted drug delivery, providing a promising strategy for precise and efficient treatment of nasopharyngeal carcinoma.