Scholarlink

<p>In this study, superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized via a chemical co-precipitation method and surface functionalized with four hydrophilic biopolymers: polyethylene glycol (PEG), polyvinyl alcohol (PVA), hydroxypropyl methylcellulose (HPMC), and chitosan. A systematic comparative evaluation was performed to understand how each polymer influences nanoparticle morphology, oxidation resistance, colloidal stability, and magnetic performance. The comprehensive characterization using FTIR, SEM, DLS, zeta potential analysis, VSM, Mossbauer spectroscopy, and AC/DC magnetization confirmed the successful surface modification and phase stability of magnetite and hematite structures. All polymer coatings effectively reduced agglomeration and synthesized nanoparticles predominantly in a spherical shape, with diameters ranging from 30 to 80&#xa0;nm. Magnetic measurements revealed the retention of superparamagnetic behaviour, with saturation magnetization values ranging from 39.1 to 56.1&#xa0;A·m<sup>2</sup>/kg. Among all, chitosan-coated SPIONs exhibited superior colloidal stability and biocompatibility due to strong interfacial polymer-surface interactions. The novelty of this work lies in the direct and systematic comparison of four widely used biopolymer coatings under identical synthesis and analysis conditions, providing mechanistic insights into how surface chemistry governs magnetic functionality. Overall, this tunable surface-engineering approach enhances the biomedical potential of SPIONs, paving the way for their application in targeted drug delivery, magnetic resonance imaging, and hyperthermia-based theranostics.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Modulating Magnetic Properties of Iron Oxide Nanoparticles via Hydrophilic Polymer Surface Functionalization

  • 期刊论文

  • 发表日期：

    2026年3月2日

查看全文
  • Ankita Parmanik,
  • Anindya Bose,
  • Rudra Narayan Sahoo,
  • Julia Aleksandrovna Fedotova,
  • Andrei Andreevich Kharchanka,
  • Satoshi Ota,
  • Yasushi Takemura,
  • Varshini Aare,
  • Swati Biswas

摘要

In this study, superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized via a chemical co-precipitation method and surface functionalized with four hydrophilic biopolymers: polyethylene glycol (PEG), polyvinyl alcohol (PVA), hydroxypropyl methylcellulose (HPMC), and chitosan. A systematic comparative evaluation was performed to understand how each polymer influences nanoparticle morphology, oxidation resistance, colloidal stability, and magnetic performance. The comprehensive characterization using FTIR, SEM, DLS, zeta potential analysis, VSM, Mossbauer spectroscopy, and AC/DC magnetization confirmed the successful surface modification and phase stability of magnetite and hematite structures. All polymer coatings effectively reduced agglomeration and synthesized nanoparticles predominantly in a spherical shape, with diameters ranging from 30 to 80 nm. Magnetic measurements revealed the retention of superparamagnetic behaviour, with saturation magnetization values ranging from 39.1 to 56.1 A·m2/kg. Among all, chitosan-coated SPIONs exhibited superior colloidal stability and biocompatibility due to strong interfacial polymer-surface interactions. The novelty of this work lies in the direct and systematic comparison of four widely used biopolymer coatings under identical synthesis and analysis conditions, providing mechanistic insights into how surface chemistry governs magnetic functionality. Overall, this tunable surface-engineering approach enhances the biomedical potential of SPIONs, paving the way for their application in targeted drug delivery, magnetic resonance imaging, and hyperthermia-based theranostics.