<p>An efficient and sustainable catalytic system has been developed for the synthesis of 2-arylbenzoxazinones using a novel magnetic nanocomposite catalyst, MWCNTs/MNPs-Disulfide-Diamide-Pd(0), in a one-pot, three-component reaction. The process employs 2-iodoaniline, Mo(CO)₆, and aryl or heteroaryl bromides in combination with KOAc in an ionic liquid medium, providing a green, highly effective environment for the transformation. The MWCNTs/MNPs-Disulfide-Diamide-Pd(0) catalyst was thoroughly characterized by FT-IR, XRD, EDX, and ICP-OES, confirming its structural integrity, thermal stability, and uniform dispersion of active Pd(0) sites. The nanocomposite demonstrated remarkable catalytic activity and selectivity toward the formation of 2-arylbenzoxazinones, delivering excellent yields under mild conditions. The use of the ionic liquid not only enhanced substrate solubility and reaction kinetics but also reduced reaction time and waste generation. Notably, the catalyst exhibited outstanding reusability, maintaining high performance over eight consecutive cycles without significant loss of activity or structural degradation, which should reassure the audience of its practical sustainability. This method represents an eco-friendly, scalable approach to the synthesis of bioactive 2-arylbenzoxazinones, leveraging the synergistic advantages of nanotechnology and ionic liquid chemistry. This combination aims to inspire confidence in the method’s potential for practical, sustainable, and large-scale applications, emphasizing its role in advancing green organic synthesis. </p>