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<p>PVA/gelatin hydrogels are biocompatible polymer networks with wide range of application in bone tissue engineering. The hydrogel was incorporated with Selenium nanoparticles (SeNPs) at the concentration of 0.1, 1, and 5&#xa0;mg by solvent casting method to improve osteogenic property. Water uptake and biodegradability was assessed by swelling and degradation studies. SeNPs formation was confirmed by UV–visible spectroscopy and characterized by field emission scanning electron microscopy, X-ray diffractometry, and particle size analyser to prove crystallite nature, morphology and particle size. The functional group interactions in hydrogel was identified by fourier transform infrared spectroscopy. The material stability was validated by rheological, thermogravimetric, and mechanical analysis. Further, osteogenic property was evaluated by cell viability, alkaline phosphatase activity and mineralization assays. SeNPs-loaded hydrogels showed osteo-inductivity in concentration-dependent manner with increased cell proliferation, ALP release and calcium deposition. Thus, hydrogel exhibited potent physicochemical stability and biocompatibility providing evidence for supporting bone regeneration.</p>

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Development of Green Synthesized Selenium Nanoparticle-Embedded PVA/Gelatin Hydrogels with Enhanced Osteoinductive Properties

  • 期刊论文

  • 发表日期：

    2026年3月5日

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  • Xunkai Hou,
  • Yang Lu,
  • Abdullah A. Alarfaj,
  • Abdurrahman Hajinur Hirad

摘要

PVA/gelatin hydrogels are biocompatible polymer networks with wide range of application in bone tissue engineering. The hydrogel was incorporated with Selenium nanoparticles (SeNPs) at the concentration of 0.1, 1, and 5 mg by solvent casting method to improve osteogenic property. Water uptake and biodegradability was assessed by swelling and degradation studies. SeNPs formation was confirmed by UV–visible spectroscopy and characterized by field emission scanning electron microscopy, X-ray diffractometry, and particle size analyser to prove crystallite nature, morphology and particle size. The functional group interactions in hydrogel was identified by fourier transform infrared spectroscopy. The material stability was validated by rheological, thermogravimetric, and mechanical analysis. Further, osteogenic property was evaluated by cell viability, alkaline phosphatase activity and mineralization assays. SeNPs-loaded hydrogels showed osteo-inductivity in concentration-dependent manner with increased cell proliferation, ALP release and calcium deposition. Thus, hydrogel exhibited potent physicochemical stability and biocompatibility providing evidence for supporting bone regeneration.