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<p>A cost-effective, convenient, and green synthetic route was developed for the fabrication of CuO/ZnO bimetallic nanocomposites, using <i>Seriphidium kurramense</i> (Qazilb.) Y.R. Ling extracts. Fourier Transform Infrared spectroscopy confirmed the successful fabrication of the composites, while X-ray diffraction analysis revealed crystalline structures, with crystallite sizes varying between 8.45 and 20.026&#xa0;nm. The nanocomposites exhibited pronounced anti-microbial potential against both Gram-positive and Gram-negative bacteria, displaying superior activity than their corresponding crude extracts in order of <i>n</i>-hexane &gt; ethyl acetate &gt; <i>n</i>-butanol. The <i>n</i>-hexane nanocomposites produced 31, 33, 27, and 26&#xa0;mm zones of inhibition against <i>Pseudomonas aeruginosa</i>, <i>Escherichia coli</i>, <i>Streptococcus mutans</i>, and <i>Staphylococcus aureus</i>, respectively. Moreover, it also inhibited <i>Candida albicans</i>, significantly (25.5&#xa0;mm). Additionally, the in vitro Leishmanicidal potential against promastigotes of <i>Leishmania tropica</i> revealed prominent results. The <i>n</i>-butanol extract was found to be the most active, exhibiting 97% inhibition. Among the nanocomposites, the ethyl acetate bimetallic nanocomposites demonstrated the best activity (IC<sub>50</sub> = 0.79&#xa0;µg/200 µL), while moderate (1.30&#xa0;µg/200 µL) and weak (2.358&#xa0;µg/200 µL) leishmanicidal potential was shown by the <i>n</i>-butanol and <i>n</i>-hexane nanocomposites. Overall, these findings highlight the potential of plant-based CuO/ZnO bimetallic nanocomposites as potent anti-microbial and anti-parasitic agents, offering a route towards safer therapeutic alternatives.</p>

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Plant-Mediated Fabrication and Enhanced Anti-microbial and Leishmanicidal Activities of Bimetallic CuO/ZnO Nanocomposites

  • 期刊论文

  • 发表日期：

    2026年3月22日

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  • Zeenat Waris,
  • Majid Khan,
  • Shafqatullah,
  • Qaisar Jamal,
  • Moeen Uddin,
  • Salman Zafar

摘要

A cost-effective, convenient, and green synthetic route was developed for the fabrication of CuO/ZnO bimetallic nanocomposites, using Seriphidium kurramense (Qazilb.) Y.R. Ling extracts. Fourier Transform Infrared spectroscopy confirmed the successful fabrication of the composites, while X-ray diffraction analysis revealed crystalline structures, with crystallite sizes varying between 8.45 and 20.026 nm. The nanocomposites exhibited pronounced anti-microbial potential against both Gram-positive and Gram-negative bacteria, displaying superior activity than their corresponding crude extracts in order of n-hexane > ethyl acetate > n-butanol. The n-hexane nanocomposites produced 31, 33, 27, and 26 mm zones of inhibition against Pseudomonas aeruginosa, Escherichia coli, Streptococcus mutans, and Staphylococcus aureus, respectively. Moreover, it also inhibited Candida albicans, significantly (25.5 mm). Additionally, the in vitro Leishmanicidal potential against promastigotes of Leishmania tropica revealed prominent results. The n-butanol extract was found to be the most active, exhibiting 97% inhibition. Among the nanocomposites, the ethyl acetate bimetallic nanocomposites demonstrated the best activity (IC50 = 0.79 µg/200 µL), while moderate (1.30 µg/200 µL) and weak (2.358 µg/200 µL) leishmanicidal potential was shown by the n-butanol and n-hexane nanocomposites. Overall, these findings highlight the potential of plant-based CuO/ZnO bimetallic nanocomposites as potent anti-microbial and anti-parasitic agents, offering a route towards safer therapeutic alternatives.