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<p>A magnetically recoverable nanocomposite catalyst, Fe₃O₄@SiO₂-TCCP-Cu(II), was developed and applied to the green synthesis of imidazo[1,2-a]pyridines. The hybrid system combines the porosity of the tetrakis(4-carboxyphenyl)porphyrin (TCCP) ligand with the magnetic retrievability of Fe₃O₄ nanoparticles. Structural integrity, physical characterisations, and morphological diagnostics confirmed the successful fabrication, stability, and uniform distribution of active sites within the nanocomposite. The catalytic reactions performed in a biodegradable choline chloride–urea (ChCl–Urea) deep eutectic solvent afforded the target products in high yields (up to 98%) under air at 100&#xa0;°C, with broad substrate compatibility. The catalyst was readily separated using an external magnet and reused for eight consecutive cycles with minimal loss of activity. This work provides an efficient and environmentally benign methodology for constructing nitrogen-fused heterocycles with promising industrial and pharmaceutical relevance.</p> Graphical Abstract <p></p>

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Cu(II)-Functionalized Magnetic Fe₃O₄@SiO₂–TCCP Catalyst for the Synthesis of Imidazo[1,2-a]pyridines in Deep Eutectic Solvents

  • 期刊论文

  • 发表日期：

    2026年1月30日

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  • Mohamed Abu Shuheil,
  • Magdi E. A. Zaki,
  • G. Padma Priya,
  • Qusay Husam Aziz,
  • Y. Sasikumar,
  • Ahmed Aldulaimi,
  • Renu Sharma,
  • Sobhi M. Gomha

摘要

A magnetically recoverable nanocomposite catalyst, Fe₃O₄@SiO₂-TCCP-Cu(II), was developed and applied to the green synthesis of imidazo[1,2-a]pyridines. The hybrid system combines the porosity of the tetrakis(4-carboxyphenyl)porphyrin (TCCP) ligand with the magnetic retrievability of Fe₃O₄ nanoparticles. Structural integrity, physical characterisations, and morphological diagnostics confirmed the successful fabrication, stability, and uniform distribution of active sites within the nanocomposite. The catalytic reactions performed in a biodegradable choline chloride–urea (ChCl–Urea) deep eutectic solvent afforded the target products in high yields (up to 98%) under air at 100 °C, with broad substrate compatibility. The catalyst was readily separated using an external magnet and reused for eight consecutive cycles with minimal loss of activity. This work provides an efficient and environmentally benign methodology for constructing nitrogen-fused heterocycles with promising industrial and pharmaceutical relevance.

Graphical Abstract