Utilization of Magnetic Covalent Organic Framework (COF) as an Efficient Catalyst in the Synthesis of Nitrogen-Containing Heterocyclic Compounds: Relevance in Sports Recovery of Athletes and Regenerative Biochemistry
摘要
Efficient, environmentally friendly, and cost-effective catalytic systems are among the current research goals worldwide. In this regard, we have developed a functional covalent organic framework (Fe3O4@Tp-DABSA-COF) that can act as an efficient heterogeneous catalyst for the production of pyrimidine derivatives in an environmentally friendly and high-performance manner. A number of methods were used to identify the structure and properties of the designed catalyst, including XRD (X-ray Diffraction), BET (Brunauer–Emmett–Teller), EDS (Energy-Dispersive X-ray Spectroscopy), FT-IR (Fourier Transform Infrared Spectroscopy), TGA (Thermogravimetric Analysis), SEM (Scanning Electron Microscopy), and VSM (Vibrating Sample Magnetometry). According to the analyses, the average particle size, surface area, and mean pore diameter were 91 nm, 169 m2/g, and 1.41 nm, respectively, indicating that this material is predominantly microporous. The catalyst demonstrated excellent performance in water and at ambient temperature, yielding heterocyclic products in high to excellent yields. High saturation magnetism (Ms ≈ 35 emu/g), excellent recyclability of the catalyst, and its structural stability are its outstanding features. Since some pyrimidine-derived molecules have been shown to possess anti-inflammatory and fatigue-modulating activities, this type of catalytic strategy could be utilized to design future catalytic applications in the production of bioactive compounds to enhance endurance and sports recovery.