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<p>An efficient and straightforward solvent–free method for synthesizing triaryl imidazole derivatives via a one–pot, three–component cyclocondensation reaction is reported. Reusable La<sup>+3</sup>– doped mixed ferrite Nanocrysatline served as effective nanocatalysts. Structural characterization by X–ray diffraction (XRD) and Rietveld refinement confirmed a cubic spinel structure accompanied by a minor LaFeO<sub>3</sub> phase. Surface morphology and particle size were examined through scanning and transmission electron microscopy (SEM and TEM), revealing nanoscale particles with slight agglomeration. Magnetic properties evaluated by vibrating sample magnetometry (VSM) facilitated facile catalyst recovery. Optimization of reaction parameters, including temperature, catalyst loading, and reaction time, led to high yields (96%) and significantly reduced reaction (25&#xa0;min) durations. The protocol demonstrates cost–effectiveness, environmental friendliness, and excellent catalyst recyclability over multiple cycles. This sustainable synthetic approach offers a practical and green route to pharmaceutically important triaryl imidazole derivatives.</p>

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Reusable Magnetic La³⁺– Doped Mixed Ferrite Nanocrysatline for Green One–Pot Solvent–Free Synthesis of Triaryl Imidazole Derivatives

  • 期刊论文

  • 发表日期：

    2025年8月21日

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  • Laxman Dhale,
  • Ketankumar Ganure,
  • Sarang Joshi,
  • Chaitalee Mali,
  • Annu Kumari,
  • Udhav M Mandle

摘要

An efficient and straightforward solvent–free method for synthesizing triaryl imidazole derivatives via a one–pot, three–component cyclocondensation reaction is reported. Reusable La+3– doped mixed ferrite Nanocrysatline served as effective nanocatalysts. Structural characterization by X–ray diffraction (XRD) and Rietveld refinement confirmed a cubic spinel structure accompanied by a minor LaFeO3 phase. Surface morphology and particle size were examined through scanning and transmission electron microscopy (SEM and TEM), revealing nanoscale particles with slight agglomeration. Magnetic properties evaluated by vibrating sample magnetometry (VSM) facilitated facile catalyst recovery. Optimization of reaction parameters, including temperature, catalyst loading, and reaction time, led to high yields (96%) and significantly reduced reaction (25 min) durations. The protocol demonstrates cost–effectiveness, environmental friendliness, and excellent catalyst recyclability over multiple cycles. This sustainable synthetic approach offers a practical and green route to pharmaceutically important triaryl imidazole derivatives.