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<p>The increasing global burden of pollution-linked illnesses, rising resistance to conventional therapies, and environmental toxicity of synthetic agents underscore the urgent need for sustainable biomedical and environmental solutions. This study aims to develop eco-friendly magnesium oxide nanoparticles (MgO-NPs) using a novel fungal endophyte, <i>Daldinia</i> sp., isolated from the medicinal plant <i>Ayapana triplinervis</i>, and to evaluate their multifunctional bioactivity. The isolated fungal strain, A1 was identified as <i>Daldinia</i> sp. through molecular characterization studies. An eco-friendly myco-synthesis method was employed using the fungal filtrate of strain A1 to produce magnesium oxide nanoparticles (AT-MgONs), which were characterized to be uniform, crystalline and well-dispersed spherical structures through various spectroscopic characterization techniques. The AT-MgONs exhibited strong anticancer potential against A549 lung cancer cells by effectively disrupting cell proliferation, triggering programmed cell death and inhibiting the migration of cells. Additionally, AT-MgONs induced significant mortality in Aedes aegypti larvae, exhibiting LC₅₀ and LC₉₀ values of 52.722 and 136.163&#xa0;µg/mL respectively, against IV instar larvae and 99.548 and 214.545&#xa0;µg/mL respectively, against pupae. Further, the AT-MgONs exhibited significant photocatalytic degradation of azo dyes—achieving 55% and 88% degradation of methyl orange and methyl red respectively, within 60&#xa0;min under sunlight, following pseudo-first-order kinetics. These findings highlight the potential of endophytic fungi as sustainable platforms for green nanoparticle synthesis with dual applications in cancer therapeutics and environmental remediation.</p> Graphical Abstract Illustrating the myco-fabrication of MgO Nanoparticles (AT-MgONs) from Daldinia Sp. Isolated from A. Triplinervis, their Characterization and Multifunctional Applications in Anticancer Therapy, Mosquito Control and Photocatalytic Dye Degradation <p></p>

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Myco-Engineered Magnesium Oxide (MgO) Nanoparticles from Ayapana triplinervis Endophyte: A Dual-Functional Approach for Biomedical and Environmental Applications

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • P. Arthi,
  • K. Hema,
  • S. Vasthi Gnana Rani,
  • R. Sugarthi,
  • Ananth Sivapunniyam,
  • Thangamathi Perumal,
  • Prabu Kumar Seetharaman,
  • Karthik Raja Ramalingam,
  • C. Jayashree

摘要

The increasing global burden of pollution-linked illnesses, rising resistance to conventional therapies, and environmental toxicity of synthetic agents underscore the urgent need for sustainable biomedical and environmental solutions. This study aims to develop eco-friendly magnesium oxide nanoparticles (MgO-NPs) using a novel fungal endophyte, Daldinia sp., isolated from the medicinal plant Ayapana triplinervis, and to evaluate their multifunctional bioactivity. The isolated fungal strain, A1 was identified as Daldinia sp. through molecular characterization studies. An eco-friendly myco-synthesis method was employed using the fungal filtrate of strain A1 to produce magnesium oxide nanoparticles (AT-MgONs), which were characterized to be uniform, crystalline and well-dispersed spherical structures through various spectroscopic characterization techniques. The AT-MgONs exhibited strong anticancer potential against A549 lung cancer cells by effectively disrupting cell proliferation, triggering programmed cell death and inhibiting the migration of cells. Additionally, AT-MgONs induced significant mortality in Aedes aegypti larvae, exhibiting LC₅₀ and LC₉₀ values of 52.722 and 136.163 µg/mL respectively, against IV instar larvae and 99.548 and 214.545 µg/mL respectively, against pupae. Further, the AT-MgONs exhibited significant photocatalytic degradation of azo dyes—achieving 55% and 88% degradation of methyl orange and methyl red respectively, within 60 min under sunlight, following pseudo-first-order kinetics. These findings highlight the potential of endophytic fungi as sustainable platforms for green nanoparticle synthesis with dual applications in cancer therapeutics and environmental remediation.

Graphical Abstract Illustrating the myco-fabrication of MgO Nanoparticles (AT-MgONs) from Daldinia Sp. Isolated from A. Triplinervis, their Characterization and Multifunctional Applications in Anticancer Therapy, Mosquito Control and Photocatalytic Dye Degradation