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<p>In this paper, blue fluorescent magnetic periodic mesoporous organosilica with hollow spheres (PMOs-HS@CDs) and magnetic periodic mesoporous organosilica with mesoporous hollow spheres PMOs-MHS@CDs were both prepared by a double template method and then grafted with carbon quantum dots. Using gambogic acid (GA) as a drug model, the loading and slow-release properties of magnetic periodic mesoporous organosilica with hollow spheres PMOs-HS@CDs and magnetic periodic mesoporous organosilica with mesoporous hollow spheres PMOs-MHS@CDs for gambogic acid (GA) were investigated. The findings showed that magnetic periodic mesoporous organosilica with hollow spheres PMOs-MHS@CDs had good loading capacity with multiple layers of gambogic acid (GA) being adsorbed on the surface, and was more conducive to the sustained release of drugs in an environment of pH = 5.7. The fitting results of the slow-release kinetic equation were more consistent with the first-order kinetic equation. Both magnetic periodic mesoporous organosilica with mesoporous hollow spheres PMOs-MHS@CDs and magnetic periodic mesoporous organosilica with hollow spheres PMOs-HS@CDs exhibited low cytotoxicity towards carcinoma VX2 cells. Among these, the magnetic Technetium-99m magnetic periodic mesoporous organosilica with mesoporous hollow spheres <sup>99m</sup>Tc-PMOs-MHS@CDs demonstrated higher uptake in the liver and spleen compared to the non-magnetic Technetium-99m magnetic periodic mesoporous organosilica with hollow spheres <sup>99m</sup>Tc-PMOs-HS@CDs. This was attributed to the magnetic periodic mesoporous organosilica with mesoporous hollow spheres PMOs-MHS@CDs’ high affinity for uptake by the liver and spleen, which were organs that contained a relatively large number of fixed macrophages. The targeted Single Photon Emission Computed Tomography SPECT imaging showed a higher uptake of <sup>99m</sup>Tc labeled magnetic periodic mesoporous organosilica with mesoporous hollow spheres PMOs-MHS@CDs in carcinoma VX2 tumor area than the nontargeted tumor area. Along with efficient fluorescence imaging and drug-loading capacity, the nanocomposite exhibits dual tumor-targeting ability via external magnetic guidance and pH-responsive drug release.</p>

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Fluorescent Magnetic Periodic Mesoporous Organosilicas for Gambogic Acid Loading, Controlled Release, and Targeted Delivery To VX2 Tumor Cells

  • 期刊论文

  • 发表日期：

    2025年5月21日

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  • Yan Huang,
  • Ansa Khalid,
  • Yangxiu Xie,
  • Yuxiang Yang,
  • Weiwei Huan,
  • Hongming Yuan,
  • Chaoying Ni

摘要

In this paper, blue fluorescent magnetic periodic mesoporous organosilica with hollow spheres (PMOs-HS@CDs) and magnetic periodic mesoporous organosilica with mesoporous hollow spheres PMOs-MHS@CDs were both prepared by a double template method and then grafted with carbon quantum dots. Using gambogic acid (GA) as a drug model, the loading and slow-release properties of magnetic periodic mesoporous organosilica with hollow spheres PMOs-HS@CDs and magnetic periodic mesoporous organosilica with mesoporous hollow spheres PMOs-MHS@CDs for gambogic acid (GA) were investigated. The findings showed that magnetic periodic mesoporous organosilica with hollow spheres PMOs-MHS@CDs had good loading capacity with multiple layers of gambogic acid (GA) being adsorbed on the surface, and was more conducive to the sustained release of drugs in an environment of pH = 5.7. The fitting results of the slow-release kinetic equation were more consistent with the first-order kinetic equation. Both magnetic periodic mesoporous organosilica with mesoporous hollow spheres PMOs-MHS@CDs and magnetic periodic mesoporous organosilica with hollow spheres PMOs-HS@CDs exhibited low cytotoxicity towards carcinoma VX2 cells. Among these, the magnetic Technetium-99m magnetic periodic mesoporous organosilica with mesoporous hollow spheres 99mTc-PMOs-MHS@CDs demonstrated higher uptake in the liver and spleen compared to the non-magnetic Technetium-99m magnetic periodic mesoporous organosilica with hollow spheres 99mTc-PMOs-HS@CDs. This was attributed to the magnetic periodic mesoporous organosilica with mesoporous hollow spheres PMOs-MHS@CDs’ high affinity for uptake by the liver and spleen, which were organs that contained a relatively large number of fixed macrophages. The targeted Single Photon Emission Computed Tomography SPECT imaging showed a higher uptake of 99mTc labeled magnetic periodic mesoporous organosilica with mesoporous hollow spheres PMOs-MHS@CDs in carcinoma VX2 tumor area than the nontargeted tumor area. Along with efficient fluorescence imaging and drug-loading capacity, the nanocomposite exhibits dual tumor-targeting ability via external magnetic guidance and pH-responsive drug release.