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<p>The present work provides an environmentally benign method for the in situ-supported Au nanoparticles on the graphene oxide surface modified by chitosan polymers (GO@CS<sub>P</sub>/Au NPs). The synthesized GO@CSP/Au NPs’ physicochemical properties are further validated using a number of characterization techniques, including X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). Examination using transmission electron microscopy (TEM) and field emission scanning electron microscopy (FESEM) reveals the well-exploited morphology of GO@CSP/Au NPs. Additionally, GO@CSP/Au NPs, which have recently been produced, are employed as a nanocatalyst for the reduction of methylene blue (MB) and methyl orange (MO). Using a UV-vis spectrophotometer, the efficiency of the reduction process is monitored. Recyclability in six further deterioration cycles is employed to evaluate this catalyst’s sustainability, and the results demonstrate a consistent and noteworthy rate of degradation. Additionally, the synthesized GO@CSP/Au NPs’ cytotoxic properties were assessed against A549 lung cancer cells following MTT method. The IC<sub>50</sub> of GO@CSP/Au NPs was determined to be 35.2&#xa0;µg/mL, and they demonstrated potential anti-lung cancer efficacy against A549 cells.</p>

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Chitosan-Functionalization Graphene Oxide for Immobilizing Gold Nanoparticles: Application of Its Catalytic Performance in the Reduction of Methylene Blue and Methyl Orange and Investigation of Its Anti-lung Cancer Effects

  • 期刊论文

  • 发表日期：

    2025年3月13日

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  • Fahad M. Aldosari,
  • Attalla F. El-kott,
  • Ali S. Alshehri,
  • Mohammed A. AlShehri,
  • Essam H. Ibrahim,
  • Sally Negm,
  • Bikash Karmakar,
  • Mohamed A. Salem,
  • Mohamed Hamdy Helal

摘要

The present work provides an environmentally benign method for the in situ-supported Au nanoparticles on the graphene oxide surface modified by chitosan polymers (GO@CSP/Au NPs). The synthesized GO@CSP/Au NPs’ physicochemical properties are further validated using a number of characterization techniques, including X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). Examination using transmission electron microscopy (TEM) and field emission scanning electron microscopy (FESEM) reveals the well-exploited morphology of GO@CSP/Au NPs. Additionally, GO@CSP/Au NPs, which have recently been produced, are employed as a nanocatalyst for the reduction of methylene blue (MB) and methyl orange (MO). Using a UV-vis spectrophotometer, the efficiency of the reduction process is monitored. Recyclability in six further deterioration cycles is employed to evaluate this catalyst’s sustainability, and the results demonstrate a consistent and noteworthy rate of degradation. Additionally, the synthesized GO@CSP/Au NPs’ cytotoxic properties were assessed against A549 lung cancer cells following MTT method. The IC50 of GO@CSP/Au NPs was determined to be 35.2 µg/mL, and they demonstrated potential anti-lung cancer efficacy against A549 cells.