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<p>Abstract text goes here. Trimethoprim is a broad-spectrum antibiotic that is used in the treatment of infections, especially urinary tract infections. This antibiotic has an amine functional group that can create a Schiff base with aldehyde groups. In this study, this property was used to connect it with MOFs (Metal-Organic Frameworks) containing Ti (Titanium). After confirming Trimethoprim/Oxidized Pectin/Ti-MOF nanoplymer’s structure using SEM (Scanning Electron Microscopy)/TEM (Transmission Electron Microscopy), FT-IR (Fourier Transform Infrared), TGA (Thermogravimetric Analysis)/DTG (Differential Thermogravimetry Analysis), XRD (X-Ray Diffraction), BET (Brunauer-Emmett-Teller), EDS (Energy-Dispersive X-ray Spectroscopy) and EDS mapping, desired biological properties (antimicrobial and anticancer) were checked. The results proved that our prediction of super bioactivity of synthesized Trimethoprim/Oxidized Pectin/Ti-MOF nanoplymer is entirely correct. In the investigation of antibacterial activity (studied ageist specialized aquatic bacteria, gram-positive bacteria, gram-negative bacterial and fungal species), IZD (Inhibitory Zone Diameter), MIC (Minimum Inhibitory Concentration), and MBC (Minimum Bactericidal Concentration)/MFC (Minimum Fungicidal Concentration) were studied. Their values were obtained between 12.41 mm and 21.64 mm, 2 μg/mL to 512 μg/mL, and 4 to 1024 μg/mL, respectively. In the investigation of anticancer activity, the Half-Maximal Inhibitory Concentration (IC<sub>50</sub>) is a critical parameter used to assess the effectiveness of a compound in inhibiting the growth of cancer cells. The reported values indicate an inhibition of 19% and an IC<sub>50</sub> of 17 μg/mL, respectively.</p>

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Preparation of a Novel Trimethoprim/Oxidized Pectin/Ti-MOF Nanoplymer as a Super Bioactive Agent

  • 期刊论文

  • 发表日期：

    2025年1月4日

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  • Irfan Ahmad,
  • Munthar Kadhim Abosaoda,
  • Anjan Kumar,
  • Gaurav Sanghvi,
  • Rangaswamy Roopashree,
  • Dukhbhanjan Singh,
  • Suman Saini

摘要

Abstract text goes here. Trimethoprim is a broad-spectrum antibiotic that is used in the treatment of infections, especially urinary tract infections. This antibiotic has an amine functional group that can create a Schiff base with aldehyde groups. In this study, this property was used to connect it with MOFs (Metal-Organic Frameworks) containing Ti (Titanium). After confirming Trimethoprim/Oxidized Pectin/Ti-MOF nanoplymer’s structure using SEM (Scanning Electron Microscopy)/TEM (Transmission Electron Microscopy), FT-IR (Fourier Transform Infrared), TGA (Thermogravimetric Analysis)/DTG (Differential Thermogravimetry Analysis), XRD (X-Ray Diffraction), BET (Brunauer-Emmett-Teller), EDS (Energy-Dispersive X-ray Spectroscopy) and EDS mapping, desired biological properties (antimicrobial and anticancer) were checked. The results proved that our prediction of super bioactivity of synthesized Trimethoprim/Oxidized Pectin/Ti-MOF nanoplymer is entirely correct. In the investigation of antibacterial activity (studied ageist specialized aquatic bacteria, gram-positive bacteria, gram-negative bacterial and fungal species), IZD (Inhibitory Zone Diameter), MIC (Minimum Inhibitory Concentration), and MBC (Minimum Bactericidal Concentration)/MFC (Minimum Fungicidal Concentration) were studied. Their values were obtained between 12.41 mm and 21.64 mm, 2 μg/mL to 512 μg/mL, and 4 to 1024 μg/mL, respectively. In the investigation of anticancer activity, the Half-Maximal Inhibitory Concentration (IC50) is a critical parameter used to assess the effectiveness of a compound in inhibiting the growth of cancer cells. The reported values indicate an inhibition of 19% and an IC50 of 17 μg/mL, respectively.