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<p>Nearly 808,000 people are living with renal failure in the U.S., making it one of the leading causes of mortality in the U.S. It’s often diagnosed with the concomitant complications of anemia. Death certificates were retrieved from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiology Research (CDC WONDER) database to assess anemia and kidney failure mortality and were analyzed retrospectively from 1999 to 2023. Crude and age-adjusted mortality rates (CMRs and AAMRs, respectively) per 100,000 population were computed across various demographics and geographics, and Annual percent changes (APCs) were measured to evaluate shifts in AAMRs and CMRs. From 1999 to 2023, a total of 218,557 deaths were recorded with anemia and associated kidney failure on death certificates. The AAMR remained stable from 1999 till 2012 and declined significantly before 2015 (APC: -18.36), after which a sharp incline was seen in AAMR till 2023 (APC: 5.85). Males had higher AAMRs than females throughout the study (average AAMR males: 14.8 vs. women: 10.2). CMR increased with age, peaking in adults aged 85+. The top AAMR was noted in non-Hispanic (NH) African Americans (20.6) among race/ ethnicity. Geographically, non-metropolitan areas and the Midwest region had the highest total AAMRs (non-metropolitan areas: 13.9 and the Midwest region: 12.5). Targeted interventions and proper resource allocation are needed to address the rising shift in AAMR among different geographies and demographics.</p>

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Trends in Anemia and Kidney Failure Related Mortality (1999–2023): A 25-Year Retrospective Analysis

  • 期刊论文

  • 发表日期：

    2026年2月17日

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  • Muhammad Shaheer Bin Faheem,
  • Syed Tawassul Hassan,
  • Syed Atta Ur Rafe,
  • Fahad Nayim,
  • Anam Ashfaque,
  • Faiz Anwer

摘要

Nearly 808,000 people are living with renal failure in the U.S., making it one of the leading causes of mortality in the U.S. It’s often diagnosed with the concomitant complications of anemia. Death certificates were retrieved from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiology Research (CDC WONDER) database to assess anemia and kidney failure mortality and were analyzed retrospectively from 1999 to 2023. Crude and age-adjusted mortality rates (CMRs and AAMRs, respectively) per 100,000 population were computed across various demographics and geographics, and Annual percent changes (APCs) were measured to evaluate shifts in AAMRs and CMRs. From 1999 to 2023, a total of 218,557 deaths were recorded with anemia and associated kidney failure on death certificates. The AAMR remained stable from 1999 till 2012 and declined significantly before 2015 (APC: -18.36), after which a sharp incline was seen in AAMR till 2023 (APC: 5.85). Males had higher AAMRs than females throughout the study (average AAMR males: 14.8 vs. women: 10.2). CMR increased with age, peaking in adults aged 85+. The top AAMR was noted in non-Hispanic (NH) African Americans (20.6) among race/ ethnicity. Geographically, non-metropolitan areas and the Midwest region had the highest total AAMRs (non-metropolitan areas: 13.9 and the Midwest region: 12.5). Targeted interventions and proper resource allocation are needed to address the rising shift in AAMR among different geographies and demographics.