<p>In September 2022, Iran confronted major sociopolitical upheaval following the death of Mahsa Amini, which sparked protests across the country for several months. These events were expected to have significant psychological and emotional repercussions for Iranians living in Iran. Based on transnational theory, it was also expected these sociopolitical events would have significant impacts on the mental health of Iranians living in other countries who experienced these events through family and friends in Iran and/or social media and news. In the current study, self-reported survey data was collected online between August and December 2023 from 185 first-generation adult Iranian immigrants to the United States residing in California, New York, and Texas to examine (1) the direct effects of the emotional salience of the sociopolitical events in Iran on levels of overall distress, and (2) whether this association was moderated by emotion regulation strategies, social support, and acculturation. After controlling for participant sex and relationship status, higher emotional salience was associated with higher overall distress (<i>∆R</i>^<i>2</i> =.05, <i>p</i> =.002), however, this association was significantly weaker among participants with higher levels of acculturation (<i>∆R</i>^<i>2</i> =.07, <i>p</i> &lt;.001). This is one of the first studies to examine how the mental health of a largely understudied immigrant population may be associated with the occurrence of major sociopolitical events in their country of origin, and specific psychological and social assets that may protect against (or exacerbate) the negative influence of such events on immigrant mental health.</p>