<p>To examine the relationship between physical activity level, postural disorders and cardiopulmonary functions in university students. Regular physical activity is known to support postural balance and improve the functions of the cardiopulmonary system through its positive effects on the musculoskeletal system. In this context, considering the prevalence of sedentary lifestyle in university students, the effects of physical activity on these systems were investigated. The study was conducted with 164 volunteer students between the ages of 18–25 years studying at Sakarya University of Applied Sciences. The International Physical Activity Questionnaire (IPAQ) was used to assess the physical activity levels of the participants, the SF-36 Quality of Life Scale was used to assess quality of life, the 6&#xa0;min Walk Test (6MWT) was used to measure cardiopulmonary capacity, and the Posture Analysis Method was used to assess posture disorders. The findings of the study showed that low physical activity level was associated with postural imbalances and decreased cardiopulmonary capacity. It was observed that as the physical activity level increased, postural disorders decreased and cardiopulmonary functions improved. A positive correlation was found between physical activity levels and physical function, energy/vitality and general health subscales of SF-36 scale. In addition, 6MWT performance showed better results in individuals with higher physical activity levels. It has been demonstrated that regular physical activity supports postural balance and improves the functions of the cardiopulmonary system in university students. It is clear that interventions to increase the level of physical activity will provide significant benefits on students’ postural and cardiopulmonary health in this period when sedentary lifestyle is common. It is recommended to develop programs that encourage physical activity in universities.</p>