Purpose <p>International research findings indicate elevated rates of domestic violence during the initial COVID-19 pandemic quarantine. Yet, many of these studies are limited in scope and measurement, often focusing only on urban areas and the early weeks of lockdown. To gain a deeper understanding of the effects of quarantine and social isolation measures on sexual violence, domestic violence, and femicides, this study analyzed the geographic dispersion and frequency of violence against women (VAW) during four pandemic-related phases across all municipalities in Colombia, South America.</p> Methods <p>Employing a mixed-methods approach, this study utilizes quantitative and Geographical Information System (GIS) analyses, drawing on official crime records and socioeconomic data to examine the impact of COVID-19 quarantine policies on trends in VAW in Colombia between 2018 and 2023.</p> Results <p>An interrupted time series ARIMA analysis did not find statistically significant changes in VAW incidents during any of the quarantine and post-quarantine phases. While brief fluctuations were exhibited during the three phases of the pandemic, the geographical distribution of VAW remained consistent, with ‘hot spot’ concentrations persisting in the same areas throughout the pre-pandemic, pandemic, and post-pandemic periods. Furthermore, urbanization and higher general violent crime rates consistently predicted higher VAW rates across study periods, while the presence of armed groups and coca production were significant negative predictors, and education showed mixed results.</p> Conclusions <p>Despite limitations related to aggregate data and potential underreporting, the findings offer valuable insights for devising targeted interventions and refining gender-based violence prevention strategies.</p>