Purpose <p>Domestic and intimate partner violence (DIPV) remains a pervasive global issue, disproportionately affecting people in socioeconomically and culturally vulnerable contexts. While bystander intervention has shown promise in preventing DIPV, cultural factors critically shape individuals’ attitudes and willingness to act. This systematic review examines empirical studies investigating the influence of culture on public attitudes and bystander intentions and interventions in response to DIPV.</p> Methods <p>A systematic search was conducted across eight electronic databases and supplementary sources, covering literature published between July 2014 and July 2024. Studies were included if they were peer-reviewed, presented empirical data, and involved cross-cultural comparisons of two or more cultural groups.</p> Results <p>Nineteen studies met the inclusion criteria—seven focused on bystander intentions and interventions and twelve on public attitudes towards DIPV. Findings indicate that cultural norms, particularly those related to gender roles and power hierarchies, significantly shape tolerance of DIPV and bystander inaction. Participants from less gender-egalitarian societies consistently reported higher acceptance of DIPV and lower willingness to intervene. Nonetheless, inconsistencies across contexts suggest a complex and multifaceted cultural influence.</p> Conclusions <p>This review highlights the importance of culturally grounded approaches to DIPV prevention. It underscores the need for future research to explore a broader range of cultural settings and population groups. Insights from this review can inform the design of context-sensitive interventions aimed at fostering prosocial bystander responses and promoting cultural norms that reject violence.</p>