Purpose <p>The purpose of this paper is to conduct a systematic literature review focused on prevention initiatives for family violence among Indigenous populations in the U.S. and Canada.</p> Methods <p>The authors of this systematic review identified, critically reviewed, and synthesized findings from nine studies through searches of research databases on family violence prevention among Indigenous populations.</p> Results <p>Findings from the review highlight that skills-based, strengths-focused, culturally grounded programs targeting families, caregivers, and children have utility in the prevention of family violence among Indigenous populations. There is also some evidence that programs even with minimal cultural adaptations but that include staff cultural competency training may be beneficial in reducing family violence among Indigenous populations. Further, the resilience portfolio model and dignity literatures have great promise for the future of preventing family violence among Indigenous populations. These literatures point to the importance of a focus on strengths, culture, and intrinsic value of all people in family violence prevention work in addition to highlighting the importance of early intervention strategies to interrupt intergenerational processes contributing to high rates of family violence.</p> Conclusions <p>Future research on family violence prevention among Indigenous populations should utilize large samples, randomized trials (as long as they are acceptable by tribal/community partners), methods of data collection beyond self-report only, methods to ensure high rates of enrollment and retention, and intersectional approaches. Macro level initiatives are needed to reduce interlocking systems of oppression that drive disparities in family violence experienced by Indigenous populations.</p>