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<p>Recent advancements in sonophotodynamic therapy (SPDT) have highlighted the growing demand for the development of novel and effective sonosensitizers/sonophotosensitizers for cancer treatment. Among the various candidates, phthalocyanines have attracted significant attention due to their highly versatile molecular structures and tunable photophysical and physicochemical properties. In this study, 3-[4-(hexyl benzoate)] substituted metallophthalocyanines were synthesized with peripheral substitution and comprehensively characterized using standard spectroscopic techniques. The singlet oxygen generation efficiencies of the synthesized compounds were systematically evaluated under photochemical and sonophotochemical conditions. The results demonstrate that the newly designed phthalocyanines possess promising potential as efficient sensitizers for both PDT and SPDT applications, offering synergistic enhancement in singlet oxygen production.</p>

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Synthesis and Characterization of Novel Non-Peripheral Phthalocyanines for Efficient Singlet Oxygen Generation: Comparison of Photochemical and Sonophotochemical Methods

  • 期刊论文

  • 发表日期：

    2026年6月29日

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  • Fatma Aytan Kılıçarslan,
  • Ceren Can Karanlık,
  • Ali Erdoğmuş

摘要

Recent advancements in sonophotodynamic therapy (SPDT) have highlighted the growing demand for the development of novel and effective sonosensitizers/sonophotosensitizers for cancer treatment. Among the various candidates, phthalocyanines have attracted significant attention due to their highly versatile molecular structures and tunable photophysical and physicochemical properties. In this study, 3-[4-(hexyl benzoate)] substituted metallophthalocyanines were synthesized with peripheral substitution and comprehensively characterized using standard spectroscopic techniques. The singlet oxygen generation efficiencies of the synthesized compounds were systematically evaluated under photochemical and sonophotochemical conditions. The results demonstrate that the newly designed phthalocyanines possess promising potential as efficient sensitizers for both PDT and SPDT applications, offering synergistic enhancement in singlet oxygen production.