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<p>This study presents a simple thiosemicarbazone-derived (<i>E</i>)-2-((2-Hydroxynaphthalen-1-yl)Methylene)-N-Methyl-N-Phenylhydrazinecarbothioamide (2NP) as a probe for sensing silver (Ag<sup>+</sup>) ions in presence of other cations. Time-dependent fluorescence studies of 2NP showed selectivity towards Ag<sup>+</sup> ion with a detection limit of 58.99µM with a binding constant of 1.7 × 10<sup>2</sup> M<sup>− 1</sup>. The binding stoichiometry of 2NP + Ag complex was revealed by jobs plot analysis. Stoichiometry of the complex was further supported by <sup>1</sup>H NMR titration, ESI-TOF and DFT studies confirming the formation of 2:1 binding ratio. Upon confirmation of complex formation, probe 2NP was successfully evaluated to assess its cytotoxicity and bioimaging capability in mouse fibroblast (L929) cell lines in the presence and absence of Ag⁺ ions.</p>

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A Thiosemicarbazone-Derived Fluorescent Probe for the Detection of Silver Ions and Bioimaging Application

  • 期刊论文

  • 发表日期：

    2026年3月27日

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  • Arumugam Sreedevi,
  • Gunasekaran Prabhakaran,
  • Nattamai Bhuvanesh,
  • Malathi Mahalingam,
  • Raju Nandhakumar,
  • Gopalan Subashini

摘要

This study presents a simple thiosemicarbazone-derived (E)-2-((2-Hydroxynaphthalen-1-yl)Methylene)-N-Methyl-N-Phenylhydrazinecarbothioamide (2NP) as a probe for sensing silver (Ag+) ions in presence of other cations. Time-dependent fluorescence studies of 2NP showed selectivity towards Ag+ ion with a detection limit of 58.99µM with a binding constant of 1.7 × 102 M− 1. The binding stoichiometry of 2NP + Ag complex was revealed by jobs plot analysis. Stoichiometry of the complex was further supported by 1H NMR titration, ESI-TOF and DFT studies confirming the formation of 2:1 binding ratio. Upon confirmation of complex formation, probe 2NP was successfully evaluated to assess its cytotoxicity and bioimaging capability in mouse fibroblast (L929) cell lines in the presence and absence of Ag⁺ ions.