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<p>Mercury (Hg) ranks among the most hazardous metals. Hg<sup>2+</sup> contamination has grown to be a major concern for people worldwide. Thus, it is crucial to discover a quick, practical, and reliable method of Hg<sup>2+</sup> testing for both human health and the ecological environment. In the present study, a NIR fluorescent probe <b>TP-Hg</b> was designed for Hg<sup>2+</sup> detection based on thiopyran tetracarbonitrile by employing the Hg<sup>2+</sup>-triggered thioacetal deprotection reaction. Spectral experimental results demonstrated <b>TP-Hg</b> possessed excellent selectivity toward Hg<sup>2+</sup> (λ<sub>ex/em</sub> = 563/770 nm), with good sensitivity (LOD = 0.13 µM) and high anti-interference performance. Bioimaging assays showed that the probe <b>TP-Hg</b> enabled accurate detection of Hg<sup>2+</sup> in living cells and zebrafish. Moreover, this probe was successfully applied to detect Hg<sup>2+</sup> on test strips.</p>

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A Novel NIR Fluorescent Probe with Large Stokes Shift for the Detection of Hg2+ and its Imaging in Living Cells and Zebrafish

  • 期刊论文

  • 发表日期：

    2026年1月26日

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  • Huan Zhang,
  • Limeng Cong,
  • Cong Sun,
  • Jinwei Zhang,
  • Shuai Guo,
  • Songhua Zhu,
  • Baoze Guo,
  • Junqing Zhou,
  • Youlai Zhang

摘要

Mercury (Hg) ranks among the most hazardous metals. Hg2+ contamination has grown to be a major concern for people worldwide. Thus, it is crucial to discover a quick, practical, and reliable method of Hg2+ testing for both human health and the ecological environment. In the present study, a NIR fluorescent probe TP-Hg was designed for Hg2+ detection based on thiopyran tetracarbonitrile by employing the Hg2+-triggered thioacetal deprotection reaction. Spectral experimental results demonstrated TP-Hg possessed excellent selectivity toward Hg2+ (λex/em = 563/770 nm), with good sensitivity (LOD = 0.13 µM) and high anti-interference performance. Bioimaging assays showed that the probe TP-Hg enabled accurate detection of Hg2+ in living cells and zebrafish. Moreover, this probe was successfully applied to detect Hg2+ on test strips.