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<p>Zinc phthalocyanines can be used as exceptional chemical sensors due to their outstanding stability, strong NIR absorption, and intense fluorescence emission, which facilitate accurate analyte detection. 3-Hydroxypyridine substituted zinc phthalocyanine (ZnPcPy) has been employed as a dual probe for the fluorescent determination of biliverdin and colorimetric determination of bilirubin. The fluorescence of ZnPcPy is effectively quenched by biliverdin through a static quenching mechanism facilitated by the inner filter effect. Furthermore, when ZnPcPy interacts with bilirubin, it undergoes a distinctive color shift from colorless to pinkish-red, thereby enhancing its efficacy in colorimetric detection. This newly designed dual sensor demonstrates an impressive detection limit of 8.60 × 10<sup>− 8</sup> M and 2.42 × 10<sup>− 7</sup> M for biliverdin and bilirubin, respectively, revealing superior selectivity and sensitivity against other co-existing molecules. Additionally, the methodology has been effectively employed in artificial and real samples, delivering encouraging results.</p>

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Tailored Zinc Phthalocyanine for Dual Sensing of Biliverdin and Bilirubin Via Fluorescence and Chromogenic Mode

  • 期刊论文

  • 发表日期：

    2025年12月18日

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  • Shamna Salim,
  • Leena Rajith

摘要

Zinc phthalocyanines can be used as exceptional chemical sensors due to their outstanding stability, strong NIR absorption, and intense fluorescence emission, which facilitate accurate analyte detection. 3-Hydroxypyridine substituted zinc phthalocyanine (ZnPcPy) has been employed as a dual probe for the fluorescent determination of biliverdin and colorimetric determination of bilirubin. The fluorescence of ZnPcPy is effectively quenched by biliverdin through a static quenching mechanism facilitated by the inner filter effect. Furthermore, when ZnPcPy interacts with bilirubin, it undergoes a distinctive color shift from colorless to pinkish-red, thereby enhancing its efficacy in colorimetric detection. This newly designed dual sensor demonstrates an impressive detection limit of 8.60 × 10− 8 M and 2.42 × 10− 7 M for biliverdin and bilirubin, respectively, revealing superior selectivity and sensitivity against other co-existing molecules. Additionally, the methodology has been effectively employed in artificial and real samples, delivering encouraging results.