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<p>Pharmacological research aims to discover novel molecular structures that demonstrate potent anticancer properties. Inorganic chemists have been compelled to search for novel metal compounds that exhibit favourable actions, particularly against tumours that contribute to elevated cancer death rates. These complexes were based on benzimidazole and bipyridine and had the formula [Ru(bpy)<sub>2</sub>(L)](PF<sub>6</sub>)<sub>2</sub>, where L represents either 2-(4,5-bis (4-dimethyl aminophenyl)-1&#xa0;H-imidazol-2-yl)-1&#xa0;H-benzimidazole (1) or 2-(4,5-bis(4-fluorophenyl)-1&#xa0;H-imidazol-2-yl)-1&#xa0;H-benzimidazole (2). The characterization was done using various spectral techniques. The complex redox behaviour was examined using cyclic and differential pulse voltammetry. Furthermore, complexes 1 and 2 can effectively break down supercoiled pUC19 plasmid DNA by oxidising guanine bases, and this process is reliant on the concentration of the complexes. Furthermore, the complexes exhibited a commendable capacity to scavenge DPPH radicals. Moreover, the anticancer investigations demonstrated that the complexes display significant efficacy against the MCF-7 cancer cell line. Moreover, these compounds possess promising practical potential for development into a very effective anticancer medication.</p>

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Electrochemical Investigation, Photoactive DNA Cleavage, Computational, Antioxidant, and Anticancer Activities on Bi-Imidazole-Based Ru (II) Complexes

  • 期刊论文

  • 发表日期：

    2025年12月17日

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  • Mariya Antony John Felix,
  • Rajagopal Yogeswaran,
  • Shen-Ming Chen,
  • Mathiyalagan Kiruthika,
  • Ramasamy Elayaperumal

摘要

Pharmacological research aims to discover novel molecular structures that demonstrate potent anticancer properties. Inorganic chemists have been compelled to search for novel metal compounds that exhibit favourable actions, particularly against tumours that contribute to elevated cancer death rates. These complexes were based on benzimidazole and bipyridine and had the formula [Ru(bpy)2(L)](PF6)2, where L represents either 2-(4,5-bis (4-dimethyl aminophenyl)-1 H-imidazol-2-yl)-1 H-benzimidazole (1) or 2-(4,5-bis(4-fluorophenyl)-1 H-imidazol-2-yl)-1 H-benzimidazole (2). The characterization was done using various spectral techniques. The complex redox behaviour was examined using cyclic and differential pulse voltammetry. Furthermore, complexes 1 and 2 can effectively break down supercoiled pUC19 plasmid DNA by oxidising guanine bases, and this process is reliant on the concentration of the complexes. Furthermore, the complexes exhibited a commendable capacity to scavenge DPPH radicals. Moreover, the anticancer investigations demonstrated that the complexes display significant efficacy against the MCF-7 cancer cell line. Moreover, these compounds possess promising practical potential for development into a very effective anticancer medication.