Scholarlink

<p>Crohn’s disease (CD) involves chronic intestinal inflammation, often accompanied by abnormal zinc ion (Zn²⁺) homeostasis. Herein, we developed a multifunctional nanoplatform—1-DASA-ATPMS@2@Rg3—that integrates ginsenoside Rg3 with a DASA-modified silica-based composite for ratiometric Zn²⁺ sensing and anti-inflammatory therapy. The nanocomposite exhibited a distinct ratiometric fluorescence response to Zn²⁺, with a strong linear correlation (R² = 0.9969) between the intensity ratio (I₅₀₀/I₆₇₂) and Zn²⁺ concentration over 0–200 µM, enabling accurate quantification. Time-resolved fluorescence and zeta potential analyses confirmed Zn²⁺-induced coordination and electrostatic interactions, contributing to signal amplification. Additionally, the pH-dependent optical properties further support its adaptability to inflamed gut environments. This dual-functional nanoplatform not only enables precise Zn²⁺ monitoring—a crucial marker in CD progression—but also offers therapeutic benefits via Rg3-mediated immunomodulation, presenting a promising strategy for real-time inflammation sensing and intervention in CD.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Microbial-Modified Organosilica-Based Dual-Mode Fluorescent Probe for Zn²⁺ and pH Sensing with Potential Application in Gut Immunity Modulation

  • 期刊论文

  • 发表日期：

    2025年9月27日

查看全文
  • Qing-Qing Han,
  • Fang Chen,
  • Zhao-Lin Zhang,
  • Dong-Ya Chen

摘要

Crohn’s disease (CD) involves chronic intestinal inflammation, often accompanied by abnormal zinc ion (Zn²⁺) homeostasis. Herein, we developed a multifunctional nanoplatform—1-DASA-ATPMS@2@Rg3—that integrates ginsenoside Rg3 with a DASA-modified silica-based composite for ratiometric Zn²⁺ sensing and anti-inflammatory therapy. The nanocomposite exhibited a distinct ratiometric fluorescence response to Zn²⁺, with a strong linear correlation (R² = 0.9969) between the intensity ratio (I₅₀₀/I₆₇₂) and Zn²⁺ concentration over 0–200 µM, enabling accurate quantification. Time-resolved fluorescence and zeta potential analyses confirmed Zn²⁺-induced coordination and electrostatic interactions, contributing to signal amplification. Additionally, the pH-dependent optical properties further support its adaptability to inflamed gut environments. This dual-functional nanoplatform not only enables precise Zn²⁺ monitoring—a crucial marker in CD progression—but also offers therapeutic benefits via Rg3-mediated immunomodulation, presenting a promising strategy for real-time inflammation sensing and intervention in CD.