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<p>Abnormal SO<sub>2</sub> derivative levels can induce mitochondrial dysfunction, which is associated with liver cancer disease. The pH levels is also a significance parameter in the process of food spoilage. It is evident that developing a detection tool for SO<sub>2</sub> derivatives in biological systems and pH fluctuations in food samples is of great significance. Fluorescent probes have specificity and high selectivity, enabling sensitive determination SO<sub>2</sub> derivatives and on-site detection pH changes. Therefore, a dual-functional near-infrared fluorescent probe (probe-OH) for monitoring SO<sub>2</sub> derivatives and colorimetric sensing pH levels was constructed. The probe-OH enables rapid and sensitive determination of HSO<sub>3</sub><sup>−</sup>and “naked eye” observation pH due to its high sensitivity and excellent reversibility performance. Additionally, a smartphone application platform was successfully constructed for colorimetric recognition pH level. Meanwhile, probe-OH combined with test strips assist in colorimetric evaluation of the pH changes in meat products during spoilage, and determine the pH value in actual beverages.More importantly, the probe-OH with higher fluorescence efficiency and excellent biocompatibility, will be further applied in the imaging of liver cancer cells. It was found that it can target the mitochondria of liver cancer cells and sense intracellular SO<sub>2</sub> derivatives.This probe-OH is expected to become an effective food monitoring method and an excellent mitochondrial targeting tool.</p>

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A Dual-Functional NIR Fluorescent Probe for Detection SO2 Derivatives and Colorimetric Sensing pH as well as its Applications in Food Monitoring and Hepatoma Cells Imaging

  • 期刊论文

  • 发表日期：

    2025年7月28日

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  • Yu Zhu Yang,
  • Lei Ao,
  • Xiao Ping Mao,
  • Gui Yong Li,
  • Xiao Ye Luo,
  • Huan Li Liu,
  • Nan Jun Huang

摘要

Abnormal SO2 derivative levels can induce mitochondrial dysfunction, which is associated with liver cancer disease. The pH levels is also a significance parameter in the process of food spoilage. It is evident that developing a detection tool for SO2 derivatives in biological systems and pH fluctuations in food samples is of great significance. Fluorescent probes have specificity and high selectivity, enabling sensitive determination SO2 derivatives and on-site detection pH changes. Therefore, a dual-functional near-infrared fluorescent probe (probe-OH) for monitoring SO2 derivatives and colorimetric sensing pH levels was constructed. The probe-OH enables rapid and sensitive determination of HSO3−and “naked eye” observation pH due to its high sensitivity and excellent reversibility performance. Additionally, a smartphone application platform was successfully constructed for colorimetric recognition pH level. Meanwhile, probe-OH combined with test strips assist in colorimetric evaluation of the pH changes in meat products during spoilage, and determine the pH value in actual beverages.More importantly, the probe-OH with higher fluorescence efficiency and excellent biocompatibility, will be further applied in the imaging of liver cancer cells. It was found that it can target the mitochondria of liver cancer cells and sense intracellular SO2 derivatives.This probe-OH is expected to become an effective food monitoring method and an excellent mitochondrial targeting tool.