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<p>Herein, a fluorescent probe named <b>IsoIm-SF</b> with the isovanillin-containing imidazo backbone was developed for detecting sulfite in cellular pulmonary ventilation protection condition. In solution, the established pulmonary ventilation protection condition suggested no obvious impact on the detection. <b>IsoIm-SF</b> exhibited high sensitivity, long linear range, high steadiness, rapid response, high selectivity, and low cytotoxicity. In pulmonary cells, <b>IsoIm-SF</b> realized the imaging of both the exogenous and endogenous sulfite. Further, <b>IsoIm-SF</b> might monitor the sulfite level to indicate the pulmonary ventilation protection efficacy, including that contributed by the anesthetic treatment. This work was a challenging trial for establishing the anesthetic-related therapeutics to improve the methodology of the pulmonary ventilation protection.</p>

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A Fluorescent Probe with Isovanillin-Containing Imidazole Backbone for Detecting Sulfite in Cellular Pulmonary Ventilation Protection Condition

  • 期刊论文

  • 发表日期：

    2025年6月2日

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  • Weifeng Yan,
  • Shengyang Deng,
  • Xiaoyun Guo,
  • Rui Li

摘要

Herein, a fluorescent probe named IsoIm-SF with the isovanillin-containing imidazo backbone was developed for detecting sulfite in cellular pulmonary ventilation protection condition. In solution, the established pulmonary ventilation protection condition suggested no obvious impact on the detection. IsoIm-SF exhibited high sensitivity, long linear range, high steadiness, rapid response, high selectivity, and low cytotoxicity. In pulmonary cells, IsoIm-SF realized the imaging of both the exogenous and endogenous sulfite. Further, IsoIm-SF might monitor the sulfite level to indicate the pulmonary ventilation protection efficacy, including that contributed by the anesthetic treatment. This work was a challenging trial for establishing the anesthetic-related therapeutics to improve the methodology of the pulmonary ventilation protection.