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<p>Spontaneous breathing activity during pressure support ventilation (PSV) is not beneficial for the assessment of static compliance (C<sub>st</sub>). We designed a new scheme for determining C<sub>st</sub> during PSV and assessed its accuracy using a lung model. A Hamilton C3 ventilator was connected to an ASL5000 lung simulator that simulated different lung mechanics [system’s static compliance (C<sub>st</sub>), 30 or 60 mL/cmH<sub>2</sub>O; airway resistance (R<sub>aw</sub>), 5, 10, 15, or 20 cmH<sub>2</sub>O/(L·s)]. PSV and volume-controlled ventilation (VCV) underwent activation with tidal volume (V<sub>T</sub>) values of 5, 7, and 10&#xa0;ml/kg. Respiratory mechanics were obtained and corrected with virtual extrapolation by applying RC<sub>exp</sub> and relevant equations. The repeated change in pressure support (PS) level was set at ± 1 cmH<sub>2</sub>O. C<sub>st−PSV</sub> was determined from volume fluctuations resulting from PS level changes. The classic C<sub>st</sub> measurement was obtained with the end-inspiration approach during volume-controlled ventilation (C<sub>st−VCV</sub>). Comparing the value of C<sub>st−VCV</sub>, similar values for C<sub>st−PSV</sub> were obtained at low PS level. By changing the PS level, the estimated C<sub>st−PSV</sub> resulted in a relatively high error of about 10–15%.The novel scheme provided reliable estimated results for C<sub>st</sub> during pressure support ventilation. Despite its limited accuracy affected by the spontaneous effort participation, this scheme may help in non-invasive, uninterrupted monitoring of C<sub>st</sub>.</p>

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Non-invasive evaluation of the respiratory system’s static compliance during assisted ventilation at various pressure support levels

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  • 发表日期：

    2026年6月18日

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  • Hai Zhang,
  • Yueyang Yuan,
  • Yuqing Chen,
  • Qing Chang,
  • Feng Li

摘要

Spontaneous breathing activity during pressure support ventilation (PSV) is not beneficial for the assessment of static compliance (Cst). We designed a new scheme for determining Cst during PSV and assessed its accuracy using a lung model. A Hamilton C3 ventilator was connected to an ASL5000 lung simulator that simulated different lung mechanics [system’s static compliance (Cst), 30 or 60 mL/cmH2O; airway resistance (Raw), 5, 10, 15, or 20 cmH2O/(L·s)]. PSV and volume-controlled ventilation (VCV) underwent activation with tidal volume (VT) values of 5, 7, and 10 ml/kg. Respiratory mechanics were obtained and corrected with virtual extrapolation by applying RCexp and relevant equations. The repeated change in pressure support (PS) level was set at ± 1 cmH2O. Cst−PSV was determined from volume fluctuations resulting from PS level changes. The classic Cst measurement was obtained with the end-inspiration approach during volume-controlled ventilation (Cst−VCV). Comparing the value of Cst−VCV, similar values for Cst−PSV were obtained at low PS level. By changing the PS level, the estimated Cst−PSV resulted in a relatively high error of about 10–15%.The novel scheme provided reliable estimated results for Cst during pressure support ventilation. Despite its limited accuracy affected by the spontaneous effort participation, this scheme may help in non-invasive, uninterrupted monitoring of Cst.