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<p>The study aimed to use <i>Taxodium distichum</i> leaf extract as a capping and reducing agent to synthesize selenium nanoparticles (SeNPs) and zinc oxide nanoparticles (ZnONPs) via a green chemistry approach, as well as explore their potential applications in biomedicine and nanobiotechnology. The physical properties of the nanoparticles were characterized using different techniques. The energy dispersive X-ray analysis (EDX) verified the elemental composition of SeNPs (C, O, and Se) and ZnONPs (C, O, Zn). X-ray diffraction (XRD) analysis confirmed a hexagonal wurtzite crystal structure of ZnONPs, while SeNPs revealed an amorphous structure. The fourier transform infrared spectroscopy (FT-IR) demonstrated the importance of plant secondary metabolites in the extract during the fabrication of SeNPs and ZnONPs. In addition, the thermogravimetric analysis (TGA) diagram revealed that these biomolecules were coated on the synthesized nanoparticles; the capping agent stabilizes the nanoparticles, which helps prevent aggregation. Our nanoparticles were effectively used as green catalysts to reduce methylene blue (MB) dye. In the biological analysis, the free radical scavenging activity of the eco-friendly SeNPs and ZnONPs (DPPH assay) exhibited IC<sub>50</sub> value of were 1.51 ± 0.09&#xa0;µg/ml and 23.63 ± 0.30&#xa0;µg/ml, respectively, indicating their potent antioxidant properties. A comprehensive antibacterial study was conducted on various bacteria, including seven ATCC strains. Evaluation of the anticancer activity revealed that the IC<sub>50</sub> values of SeNPs and ZnONPs against human gastric cancer cells (AGS) were 430.8&#xa0;µg/ml and 998.7&#xa0;µg/ml, respectively. Therefore, the green SeNPs and ZnONPs are promising candidates for biomedicine and nanobiotechnology.</p>

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Taxodium distichum Leaf Extract Mediated Green Synthesis of SeNPs and ZnONPs: Optimization and Evaluation of Photocatalytic, In vitro Cytotoxicity, and Antibacterial Activities

  • 期刊论文

  • 发表日期：

    2026年4月14日

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  • Shima Joneidi,
  • Seyedeh Roya Alizadeh,
  • Pourya Biparva,
  • Hamid Reza Goli,
  • Mohammad Ali Ebrahimzadeh

摘要

The study aimed to use Taxodium distichum leaf extract as a capping and reducing agent to synthesize selenium nanoparticles (SeNPs) and zinc oxide nanoparticles (ZnONPs) via a green chemistry approach, as well as explore their potential applications in biomedicine and nanobiotechnology. The physical properties of the nanoparticles were characterized using different techniques. The energy dispersive X-ray analysis (EDX) verified the elemental composition of SeNPs (C, O, and Se) and ZnONPs (C, O, Zn). X-ray diffraction (XRD) analysis confirmed a hexagonal wurtzite crystal structure of ZnONPs, while SeNPs revealed an amorphous structure. The fourier transform infrared spectroscopy (FT-IR) demonstrated the importance of plant secondary metabolites in the extract during the fabrication of SeNPs and ZnONPs. In addition, the thermogravimetric analysis (TGA) diagram revealed that these biomolecules were coated on the synthesized nanoparticles; the capping agent stabilizes the nanoparticles, which helps prevent aggregation. Our nanoparticles were effectively used as green catalysts to reduce methylene blue (MB) dye. In the biological analysis, the free radical scavenging activity of the eco-friendly SeNPs and ZnONPs (DPPH assay) exhibited IC50 value of were 1.51 ± 0.09 µg/ml and 23.63 ± 0.30 µg/ml, respectively, indicating their potent antioxidant properties. A comprehensive antibacterial study was conducted on various bacteria, including seven ATCC strains. Evaluation of the anticancer activity revealed that the IC50 values of SeNPs and ZnONPs against human gastric cancer cells (AGS) were 430.8 µg/ml and 998.7 µg/ml, respectively. Therefore, the green SeNPs and ZnONPs are promising candidates for biomedicine and nanobiotechnology.