Scholarlink

<p>In this study, silica-coated magnetic nanoparticles (MNPs@SiO<sub>2</sub>) were synthesized using <i>Curcuma longa</i> (turmeric) leaf extract as a natural reducing and stabilizing agent. This eco-friendly synthesis eliminates the use of toxic chemicals, making the process sustainable and economically viable. The primary goal of the research was to explore the potential anticancer properties of the synthesized nanoparticles. Comprehensive characterization confirmed uniform spherical morphology with an average particle size of 48.2 ± 5 to 54.4 ± 4.5 (mean ± SD nm), a specific surface area of 71.22&#xa0;m²/g, and magnetic saturation values of 0.38 emu/g for MNPs and 0.16 emu/g for MNPs@SiO<sub>2</sub>. The cytotoxicity of the nanoparticles was evaluated against human breast cancer cells (MDA-MB-231) using the MTT assay. Cell death percentages for 10–50 ng/mL concentrations ranged from 2.7 ± 3.1% to 23.9 ± 4.5%, showing a dose-dependent inhibition pattern with an IC<sub>50</sub> value of 100.97 ng/mL, indicating notable anticancer efficacy. The observed cytotoxicity is attributed to synergistic effects between the magnetic core and bioactive phytochemicals from turmeric extract.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Green Synthesis of MNPs@SiO2 Nanoparticles Using Turmeric Leaf Extract: Structural Characterization, and their Anticancer Activities in MDA-MB-231 Cell Line

  • 期刊论文

  • 发表日期：

    2026年3月11日

查看全文
  • Hema Sahu,
  • Chandrakant Thakur,
  • Kavita Tapadia

摘要

In this study, silica-coated magnetic nanoparticles (MNPs@SiO2) were synthesized using Curcuma longa (turmeric) leaf extract as a natural reducing and stabilizing agent. This eco-friendly synthesis eliminates the use of toxic chemicals, making the process sustainable and economically viable. The primary goal of the research was to explore the potential anticancer properties of the synthesized nanoparticles. Comprehensive characterization confirmed uniform spherical morphology with an average particle size of 48.2 ± 5 to 54.4 ± 4.5 (mean ± SD nm), a specific surface area of 71.22 m²/g, and magnetic saturation values of 0.38 emu/g for MNPs and 0.16 emu/g for MNPs@SiO2. The cytotoxicity of the nanoparticles was evaluated against human breast cancer cells (MDA-MB-231) using the MTT assay. Cell death percentages for 10–50 ng/mL concentrations ranged from 2.7 ± 3.1% to 23.9 ± 4.5%, showing a dose-dependent inhibition pattern with an IC50 value of 100.97 ng/mL, indicating notable anticancer efficacy. The observed cytotoxicity is attributed to synergistic effects between the magnetic core and bioactive phytochemicals from turmeric extract.

Graphical Abstract