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<p>Stimuli-response polymeric nanoparticles have emerged as a nanocarrier in the drug delivery systems. In this study, for the first time, a novel stimuli-responsive nanocarrier was synthesized with the combination of N-vinylcaprolactam, allyl alcohol, and carbon disulfide on the tungsten disulfide nanosheets for palbociclib delivery by near-infrared laser irradiation. The successful synthesis of this system was confirmed by different techniques. Response surface methodology and central composite design were applied to optimize conditions. The data shown that the highest sorption efficiency of drug was reached using the nanoadsorbent at pH = 4, contact time of 50&#xa0;min, initial drug concentration of 20 mg L<sup>− 1</sup>, and temperature of 28&#xa0;°C. The non-linear analysis indicated that drug sorption fitted well with the pseudo-second-order kinetic model and the Langmuir isotherm model. The in vitro drug release from the nanocarrier was noticeably dependent on pH and temperature. In vitro drug release experiments indicated that the obtained nanocarrier controlled the release of the drug at a temperature of 45&#xa0;°C and pH = 5.6, achieving 88.48 ± 0.26% release over 6&#xa0;h. Additionally, most of the drug was released from the nanocarrier within 15&#xa0;min (&gt; 98%) under near-infrared laser irradiation. Furthermore, the prepared drug delivery system demonstrated that the drug release followed a non-Fickian diffusion mechanism with <i>n</i> = 0.5.</p>

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Functionalized Tungsten Disulfide Nanosheets-Based Polymer Composites as a Nanocarrier for Smart NIR- Responsive Drug Delivery Systems

  • 期刊论文

  • 发表日期：

    2025年12月21日

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  • Maryam Asgarzadeh,
  • Amir Heydarinasab,
  • Elham Moniri,
  • Homayon Ahmad Panahi

摘要

Stimuli-response polymeric nanoparticles have emerged as a nanocarrier in the drug delivery systems. In this study, for the first time, a novel stimuli-responsive nanocarrier was synthesized with the combination of N-vinylcaprolactam, allyl alcohol, and carbon disulfide on the tungsten disulfide nanosheets for palbociclib delivery by near-infrared laser irradiation. The successful synthesis of this system was confirmed by different techniques. Response surface methodology and central composite design were applied to optimize conditions. The data shown that the highest sorption efficiency of drug was reached using the nanoadsorbent at pH = 4, contact time of 50 min, initial drug concentration of 20 mg L− 1, and temperature of 28 °C. The non-linear analysis indicated that drug sorption fitted well with the pseudo-second-order kinetic model and the Langmuir isotherm model. The in vitro drug release from the nanocarrier was noticeably dependent on pH and temperature. In vitro drug release experiments indicated that the obtained nanocarrier controlled the release of the drug at a temperature of 45 °C and pH = 5.6, achieving 88.48 ± 0.26% release over 6 h. Additionally, most of the drug was released from the nanocarrier within 15 min (> 98%) under near-infrared laser irradiation. Furthermore, the prepared drug delivery system demonstrated that the drug release followed a non-Fickian diffusion mechanism with n = 0.5.