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<p>Candidiasis is a fungal infection caused by several species of the <i>Candida</i> genus. These fungi are pleomorphic, and some of them make up the human microbiota, colonizing mucous areas and the skin. The interaction between the host immune system and the microbiota is crucial for maintaining homeostasis, but dysregulation can lead to fungal adaptation and pathogenesis. Candidiasis encompasses a diverse spectrum of clinical forms, including vulvovaginal, mucocutaneous and systemic infections. The need for early diagnosis, preventive measures and effective therapeutic approaches is urgent, considering the increase in resistant biofilm-producing fungi. In this sense, nanotechnology emerges as a promising therapeutic strategy against fungal infections caused by <i>Candida spp.</i> Nanostructures such as liposomes, polymeric nanoparticles and metallic nanoparticles, metal oxides, nanocomposites or quantum dots stand out for demonstrating advantages including maintaining the plasma concentration of active ingredients, reducing toxicity, increasing bioavailability and enhancing antifungal effects. This work focuses on <i>Candida</i> species of high priority for global public health, exploring how nanotechnology can improve current treatments, offering new avenues for the management of candidiasis.</p>

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Candidiasis: Therapeutic Approaches Based on Nanotechnology

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • Luís André de Almeida Campos,
  • Gabriel de Albuquerque Moura,
  • Hanne Lazla Rafael de Queiroz Macêdo,
  • Azael Francisco Silva Neto,
  • Alessandra Silva Araújo,
  • Isabella Macário Ferro Cavalcanti

摘要

Candidiasis is a fungal infection caused by several species of the Candida genus. These fungi are pleomorphic, and some of them make up the human microbiota, colonizing mucous areas and the skin. The interaction between the host immune system and the microbiota is crucial for maintaining homeostasis, but dysregulation can lead to fungal adaptation and pathogenesis. Candidiasis encompasses a diverse spectrum of clinical forms, including vulvovaginal, mucocutaneous and systemic infections. The need for early diagnosis, preventive measures and effective therapeutic approaches is urgent, considering the increase in resistant biofilm-producing fungi. In this sense, nanotechnology emerges as a promising therapeutic strategy against fungal infections caused by Candida spp. Nanostructures such as liposomes, polymeric nanoparticles and metallic nanoparticles, metal oxides, nanocomposites or quantum dots stand out for demonstrating advantages including maintaining the plasma concentration of active ingredients, reducing toxicity, increasing bioavailability and enhancing antifungal effects. This work focuses on Candida species of high priority for global public health, exploring how nanotechnology can improve current treatments, offering new avenues for the management of candidiasis.