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<p>In recent years, chemotherapy has been widely reported as a treatment for cancer. However, most patients experience side effects of chemotherapy due to direct exposure of drugs such as doxorubicin to body tissues. This work seeks an effective magnetic-based drug delivery system, where the system can maximally load the drug and is able to release the drug in a controlled manner. In this study, the magnetite/hydroxyapatite/chitosan nanocomposite was synthesized through the coprecipitation route, utilizing the natural resources of iron sand and serai snail shells. The crystals formed are sized 9.22–9.63&#xa0;nm for magnetite and 7.94–8.70&#xa0;nm for hydroxyapatite. Infrared analysis has shown the presence of M–O, OH<sup>–</sup>, PO<sub>4</sub><sup>3–</sup>, and NH<sub>2</sub>. Additionally, morphology of the magnetite/hydroxyapatite/chitosan nanocomposite consists of spherical particles with a size of 28.1–32.3&#xa0;nm. Composition of chitosan reducing the band gap energy. The nanocomposites showed superparamagnetic with a saturation magnetization of 8.9–11.1 emu.g<sup>–1</sup>. Antibacterial activity investigations revealed that the nanocomposites formed an inhibition zone diameter of 2–8&#xa0;mm. Doxorubicin was successfully loaded with a drug loading efficiency ranging from 76 to 82%. Based on the release kinetics, doxorubicin demonstrated a rapid release with maximum value within the first 135&#xa0;min. Therefore, this study has successfully developed a drug delivery system responsive to magnetic fields, capable of loading high-capacity drugs and releasing them at target sites, thereby positioning this material as a promising candidate in cancer treatment systems.</p>

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Natural-Based Magnetite/Hydroxyapatite/Chitosan Nanocomposite as Effective Drug Delivery Systems

  • 期刊论文

  • 发表日期：

    2025年6月19日

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  • Rizka Utami,
  • Muhammad Hisyam Habani,
  • Sunaryono Sunaryono,
  • Munasir Munasir,
  • Nor Suriani Sani,
  • Erlina Yustanti,
  • Dahlang Tahir,
  • Ahmad Taufiq

摘要

In recent years, chemotherapy has been widely reported as a treatment for cancer. However, most patients experience side effects of chemotherapy due to direct exposure of drugs such as doxorubicin to body tissues. This work seeks an effective magnetic-based drug delivery system, where the system can maximally load the drug and is able to release the drug in a controlled manner. In this study, the magnetite/hydroxyapatite/chitosan nanocomposite was synthesized through the coprecipitation route, utilizing the natural resources of iron sand and serai snail shells. The crystals formed are sized 9.22–9.63 nm for magnetite and 7.94–8.70 nm for hydroxyapatite. Infrared analysis has shown the presence of M–O, OH–, PO43–, and NH2. Additionally, morphology of the magnetite/hydroxyapatite/chitosan nanocomposite consists of spherical particles with a size of 28.1–32.3 nm. Composition of chitosan reducing the band gap energy. The nanocomposites showed superparamagnetic with a saturation magnetization of 8.9–11.1 emu.g–1. Antibacterial activity investigations revealed that the nanocomposites formed an inhibition zone diameter of 2–8 mm. Doxorubicin was successfully loaded with a drug loading efficiency ranging from 76 to 82%. Based on the release kinetics, doxorubicin demonstrated a rapid release with maximum value within the first 135 min. Therefore, this study has successfully developed a drug delivery system responsive to magnetic fields, capable of loading high-capacity drugs and releasing them at target sites, thereby positioning this material as a promising candidate in cancer treatment systems.