Scholarlink

<p>Gastric cancer remains one of the leading causes of cancer-related mortality worldwide, posing significant therapeutic challenges due to its aggressive nature and limited treatment efficacy. Resveratrol (Res), a natural polyphenol, has demonstrated promising anti-gastric cancer properties by inducing apoptosis, inhibiting proliferation, and suppressing metastasis. However, its clinical application is hindered by poor water solubility and low physicochemical stability. To improve and maintain the anti-gastric cancer activity and stability of Res, this study developed a novel sustained-release nano formulation of resveratrol using polyethylene glycol–poly (lactic-co-glycolic acid) (PEG-PLGA) as a nanocarrier. The formulation was optimized via a Box–Behnken design to enhance drug encapsulation efficiency and control release kinetics. Compared with free resveratrol, Res-PEG-PLGA nanoparticles exhibited sustained release for nearly 10 hours. Furthermore, MTT assays demonstrated that Res-PEG-PLGA nanoparticles significantly enhanced the cytotoxicity and growth inhibition of resveratrol against SGC-7901 gastric cancer cells. This innovative approach offers a promising strategy for enhancing the therapeutic efficacy of resveratrol in gastric cancer treatment.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Box–Behnken Optimized Sustained-Release PEG-PLGA Nanoparticles for Enhanced Cytotoxicity of Resveratrol Against Gastric Cancer Cells

  • 期刊论文

  • 发表日期：

    2025年6月14日

查看全文
  • Mengting Wu,
  • Jiang Xia,
  • Yang Hu,
  • Hui Song,
  • Wenlan Li,
  • Wenjun Zhang

摘要

Gastric cancer remains one of the leading causes of cancer-related mortality worldwide, posing significant therapeutic challenges due to its aggressive nature and limited treatment efficacy. Resveratrol (Res), a natural polyphenol, has demonstrated promising anti-gastric cancer properties by inducing apoptosis, inhibiting proliferation, and suppressing metastasis. However, its clinical application is hindered by poor water solubility and low physicochemical stability. To improve and maintain the anti-gastric cancer activity and stability of Res, this study developed a novel sustained-release nano formulation of resveratrol using polyethylene glycol–poly (lactic-co-glycolic acid) (PEG-PLGA) as a nanocarrier. The formulation was optimized via a Box–Behnken design to enhance drug encapsulation efficiency and control release kinetics. Compared with free resveratrol, Res-PEG-PLGA nanoparticles exhibited sustained release for nearly 10 hours. Furthermore, MTT assays demonstrated that Res-PEG-PLGA nanoparticles significantly enhanced the cytotoxicity and growth inhibition of resveratrol against SGC-7901 gastric cancer cells. This innovative approach offers a promising strategy for enhancing the therapeutic efficacy of resveratrol in gastric cancer treatment.

Graphical Abstract