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<p><i>In this study</i>,<i> Foeniculum vulgare</i> seed-mediated AgNPs were deposited onto the surface of MOF-derived CeO₂. The structural, elemental, chemical, functional, and morphological properties of the Ag-CeO₂ NC were characterized using XRD, EDX, FTIR, SEM, and HR-TEM techniques. XRD results indicate the presence of AgNPs and CeO₂ NPs in the composite. FTIR studies revealed seven different functional groups in the composite. SEM and TEM results indicate the spherical-shaped AgNPs are well distributed on the CeO₂ flakes. EDS analysis confirms the presence of Ce, Ag, and O in the synthesized composite. Ag-CeO₂ nanocomposite exhibited significant antibacterial activity against <i>S. aureus</i>, <i>P. aeruginosa</i>, <i>B. substilis</i>, and <i>E. coli</i>. The minimum inhibitory concentration (MIC) values were achieved at concentrations of 60–80&#xa0;µg/mL, with optimal activity observed at 80&#xa0;µg/mL, resulting in zone of clearance values of 10.23 ± 0.46&#xa0;mm against <i>Staphylococcus aureus</i>, 6.09 ± 0.13&#xa0;mm against <i>Pseudomonas aeruginosa</i>, 11.29 ± 0.39&#xa0;mm against <i>Bacillus subtilis</i> and 11.25 ± 0.45&#xa0;mm against <i>E. coli</i>. These results suggest that the Ag-CeO₂ nanocomposite has potential as an effective antibacterial agent. Furthermore, the anticancer potential of the Ag-CeO<sub>2</sub> NC was assessed on MCF-7 human breast cancer cells. The MTT assay showed that cell viability decreased with increasing Ag-CeO₂ NC concentrations, ranging from 2.5 to 50&#xa0;µg/mL. Overall, the synthesized Ag-CeO<sub>2</sub> NC demonstrates promise as an effective agent against bacterial infections and cancer cell proliferation.</p>

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Antibacterial and Anticancer Activity of Ag-CeO2 Nanocomposite

  • 期刊论文

  • 发表日期：

    2025年6月22日

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  • P. C. Nagajyothi,
  • Kuruvalli Gouthami,
  • Subhasish Maity,
  • K. Pavani,
  • Clement Okraku Tettey,
  • Vaddi Damodara Reddy,
  • Jaesool Shim

摘要

In this study, Foeniculum vulgare seed-mediated AgNPs were deposited onto the surface of MOF-derived CeO₂. The structural, elemental, chemical, functional, and morphological properties of the Ag-CeO₂ NC were characterized using XRD, EDX, FTIR, SEM, and HR-TEM techniques. XRD results indicate the presence of AgNPs and CeO₂ NPs in the composite. FTIR studies revealed seven different functional groups in the composite. SEM and TEM results indicate the spherical-shaped AgNPs are well distributed on the CeO₂ flakes. EDS analysis confirms the presence of Ce, Ag, and O in the synthesized composite. Ag-CeO₂ nanocomposite exhibited significant antibacterial activity against S. aureus, P. aeruginosa, B. substilis, and E. coli. The minimum inhibitory concentration (MIC) values were achieved at concentrations of 60–80 µg/mL, with optimal activity observed at 80 µg/mL, resulting in zone of clearance values of 10.23 ± 0.46 mm against Staphylococcus aureus, 6.09 ± 0.13 mm against Pseudomonas aeruginosa, 11.29 ± 0.39 mm against Bacillus subtilis and 11.25 ± 0.45 mm against E. coli. These results suggest that the Ag-CeO₂ nanocomposite has potential as an effective antibacterial agent. Furthermore, the anticancer potential of the Ag-CeO2 NC was assessed on MCF-7 human breast cancer cells. The MTT assay showed that cell viability decreased with increasing Ag-CeO₂ NC concentrations, ranging from 2.5 to 50 µg/mL. Overall, the synthesized Ag-CeO2 NC demonstrates promise as an effective agent against bacterial infections and cancer cell proliferation.