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<p>The synthesised complex dichlorido(<i>η</i><sup>6</sup>-<i>p</i>-cymene)(triphenylstibine)ruthenium(II), crystallises as a dichloromethane solvate in the triclinic space group <i>P</i><InlineEquation ID="IEq1"> <EquationSource Format="TEX">\(\:\stackrel{-}{1}\)</EquationSource> </InlineEquation>, with <i>a</i> = 11.2072(7) Å, <i>b</i> = 13.3092(9) Å, <i>c</i> = 19.2307(13) Å, <i>α</i> = 91.776(2)°, <i>β</i> = 106.364(2)°, <i>γ</i> = 91.230(2)° and <i>Z</i> = 4. The bulky SbPh<sub>3</sub> ligand imposes a significant steric effect on the metal centre, as reflected by a buried volume of 24.6% in the title compound. In silico ADMET predictions suggest that the complex may act as an antagonist at cannabinoid receptors CB1 and CB2.</p> Graphical abstract

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Synthesis, Crystal Structure, Hirshfeld Surface and Molecular Docking Analysis of Dichlorido(η6-p-cymene) (Triphenylstibine)Ruthenium(II)

  • 期刊论文

  • 发表日期：

    2025年11月27日

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  • Rufaro Razuwika,
  • Zanele G. Morerwa,
  • Hadley S. Clayton

摘要

The synthesised complex dichlorido(η6-p-cymene)(triphenylstibine)ruthenium(II), crystallises as a dichloromethane solvate in the triclinic space group P \(\:\stackrel{-}{1}\) , with a = 11.2072(7) Å, b = 13.3092(9) Å, c = 19.2307(13) Å, α = 91.776(2)°, β = 106.364(2)°, γ = 91.230(2)° and Z = 4. The bulky SbPh3 ligand imposes a significant steric effect on the metal centre, as reflected by a buried volume of 24.6% in the title compound. In silico ADMET predictions suggest that the complex may act as an antagonist at cannabinoid receptors CB1 and CB2.

Graphical abstract