<p>Post-traumatic stress disorder (PTSD) and obsessive-compulsive disorder (OCD) can co-occur, yet few studies examine the associations among trauma exposure, OCD symptoms, and self-stigma. This study used self-reported measures to investigate OCD symptom levels and self-stigma in 137 college students across individuals with no trauma exposure (<i>n</i> = 63), trauma exposure only (<i>n</i> = 50), and trauma exposure but with probable PTSD (<i>n =</i> 24). Aim 1 examined average OCD symptom severity across trauma groups. We hypothesized that the probable PTSD and trauma exposure only groups would report greater average OCD symptoms compared to the no trauma exposure group. Aim 2a examined self-stigma across groups, and we predicted that those with probable PTSD would have the highest levels of self-stigma, followed by the trauma exposure only and no trauma exposure groups, respectively. Lastly, Aim 2b took an exploratory approach in investigating OCD symptoms as a potential moderator between the association of trauma exposure and self-stigma. Results indicated the probable PTSD group had higher average OCD symptoms compared to the other groups (<i>p</i> = .001), and self-stigma did not differ significantly between groups (<i>p</i> = .35). Moreover, OCD symptoms moderated the association between the trauma exposure only group and self-stigma, such that the trauma exposure only group was associated with significantly lower self-stigma than the no trauma exposure group when OCD symptoms were low (<i>p</i> = .004). These results underscore the importance of understanding comorbid PTSD and OCD symptoms and the influence of OCD symptoms on the relationship between trauma exposure and self-stigma. Future studies should examine these relationships in larger, more representative samples.</p>